Invitrogen

Phospho-PKC mu (Ser916) Polyclonal Antibody

查看其他24个PKC mu抗体

产品信息

PA5-17862

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:1,000

-

免疫沉淀 (IP)

1:100

-

产品规格

种属反应

Human, Mouse, Non-human primate, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Synthetic phosphopeptide corresponding to residues surrounding pSer916 of mouse PKD

查看免疫原

偶联物

Unconjugated

形式

Liquid

纯化类型

Antigen affinity chromatography

保存液

0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol

内含物

no preservative

保存条件

-20°C

RRID

AB_10985949

产品详细信息

It is not recommended to aliquot this antibody.

靶标信息

PKC mu (protein kinase C mu, PRKD1) is a serine/threonine kinase whose activation is dependent on the phosphorylation of two activation loop sites, Ser744 and Ser748, via a PKC-dependent signaling pathway. In addition to the two activation loop sites, the carboxy-terminal Ser916 has been identified as an autophosphorylation site for PKD/PKCu. Phosphorylation at Ser916 correlates with PKD/PKCu catalytic activity. PKC mu is one of the PKC family members, and the protein binds to the trans-Golgi network and regulates the fission of transport carriers specifically destined to the cell surface. Members of the protein kinase C (PKC) family function in many extracellular receptor-mediated signal transduction pathways.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: DKFZP586E0820; nPKC-D1; nPKC-D2; nPKC-mu; nPKC-nu; PKC mu; PKC nu; PKC u; PKC v; PKC-u; PKC-v; PKCmu; PKCu; PKCv; Protein kinase C mu type; Protein kinase C nu type; protein kinase C, mu; protein kinase C, nu; Protein kinase D; Protein kinase EPK2; Serine/threonine-protein kinase D1; Serine/threonine-protein kinase D2; Serine/threonine-protein kinase D3

基因别名: 4930557O20Rik; 5730497N19Rik; AI325941; EPK2; HSPC187; nPKC-D1; nPKC-D2; nPKC-mu; nPKC-NU; PKC-MU; PKC-NU; PKCM; Pkcnu; PKD; PKD1; PKD2; PKD3; PRKCM; PRKCN; PRKD1; PRKD2; PRKD3; RGD1308054

UniProt ID: (Human) Q15139, (Human) Q9BZL6, (Human) O94806, (Mouse) Q62101, (Rat) Q9WTQ1, (Rat) Q5XIS9, (Mouse) Q8BZ03, (Mouse) Q8K1Y2

Entrez Gene ID: (Human) 5587, (Human) 25865, (Human) 23683, (Mouse) 18760, (Rat) 85421, (Rat) 292658, (Mouse) 101540, (Rat) 313834, (Mouse) 75292

分子生物学功能: non-receptor serine/threonine protein kinase

angiogenesis positive regulation of endothelial cell proliferation protein phosphorylation apoptotic process inflammatory response Golgi organization signal transduction integrin-mediated signaling pathway Ras protein signal transduction cell proliferation positive regulation of endothelial cell migration regulation of keratinocyte proliferation positive regulation of neuron projection development peptidyl-serine phosphorylation sphingolipid biosynthetic process regulation of protein stability positive regulation of CREB transcription factor activity positive regulation of peptidyl-serine phosphorylation cellular response to oxidative stress intracellular signal transduction cellular response to vascular endothelial growth factor stimulus positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of blood vessel endothelial cell migration innate immune response positive regulation of osteoblast differentiation positive regulation of angiogenesis negative regulation of endocytosis positive regulation of transcription from RNA polymerase II promoter protein autophosphorylation vascular endothelial growth factor receptor signaling pathway Golgi vesicle transport positive regulation of NF-kappaB transcription factor activity regulation of release of sequestered calcium ion into cytosol negative regulation of cell death protein kinase D signaling positive regulation of histone deacetylase activity positive regulation of endothelial cell chemotaxis regulation of integrin-mediated signaling pathway adaptive immune response cell adhesion cell death positive regulation of vascular endothelial growth factor receptor signaling pathway positive regulation of interleukin-2 production positive regulation of interleukin-8 production positive regulation of fibroblast growth factor receptor signaling pathway positive regulation of cell adhesion T cell receptor signaling pathway positive regulation of T cell receptor signaling pathway positive regulation of sequence-specific DNA binding transcription factor activity endothelial tube morphogenesis positive regulation of ERK1 and ERK2 cascade mitophagy in response to mitochondrial depolarization positive regulation of intracellular signal transduction positive regulation of DNA biosynthetic process protein kinase C-activating G-protein coupled receptor signaling pathway immune system process nervous system development phosphorylation cell differentiation

参与通路

protein serine/threonine kinase activity protein kinase C activity protein binding ATP binding kinase activity identical protein binding metal ion binding protein kinase activity nucleotide binding transferase activity transferase activity, transferring phosphorus-containing groups