A suggested positive control for Western blot is 293 cells; suggested positive control for IHC is human lung carcinoma.
Protein Kinase C (PKC) isoforms are serine/threonine kinases involved in signal transduction pathways that govern a wide range of physiological processes including differentiation, proliferation, gene expression, brain function, membrane transport and the organization of cytoskeletal and extracellular matrix proteins. Increasing evidence from studies using in vitro and in vivo systems points to PKC as a key regulator of critical cell cycle transitions, including cell cycle entry and exit and the G1 and G2 checkpoints. PKC-mediated control of these transitions can be negative or positive, depending on the timing of PKC activation during the cell cycle and on the specific PKC isozymes involve. There have been at least 12 different PKC isoforms identified in humans to date, including alpha, beta I, beta II, gamma, delta, epsilon, zeta, eta, theta, iota, lambda, and mu. The different PKC isoforms vary in structure, subcellular localization, tissue distribution and response to extracellular signals. PKC beta II has been shown to be expressed, in part, in cardiac muscle, intestinal epithelium, kidney and pancreas. PKC beta II has been shown to be involved in cell cycle progression and cancer proliferation.
蛋白别名: EC 18.104.22.168; kinase nPKC-theta; KPCT; MGC126514; MGC141919; nPKC-theta; Protein kinase C theta type; protein kinase C, theta; RP11-563J2.1
基因别名: nPKC-theta; PRKCQ; PRKCT
UniProt ID: (Human) Q04759
Entrez Gene ID: (Human) 5588