Search

  • 联系我们
  • 货号直购

Invitrogen

Phospho-PKC zeta/gamma (Thr410, Thr412) Recombinant Rabbit Monoclonal Antibody (K01_2L07)

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}

说明书
证书
实验方案
问题与答案
技术支持
说明书
证书
实验方案
问题与答案
技术支持
说明书
证书
实验方案
问题与答案
技术支持
Additional Information:
{{banner.description}}
{{$ctrl.isSkuNotesCollapsed ? 'View more' : 'View less'}}

产品信息

MA567870

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:500-1:1,000
-

免疫组化（石蜡） (IHC (P))

1:50-1:100
-
产品规格

种属反应

Human, Mouse

宿主/亚型

Rabbit / IgG

Expression System

HEK293F

分类

Recombinant Monoclonal

类型

Antibody

克隆号

K01_2L07

抗原

A synthetic phosphopeptide corresponding to residues surrounding Thr410 of human PKC zeta.

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

规格

100 µg

纯化类型

Protein A/G

保存液

50mM tris glycine, pH 7.4, with 40% glycerol, 0.05% BSA, 150mM NaCl

内含物

0.01% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Wet ice (international)

靶标信息

Protein kinase C zeta and protein kinase C gamma are members of the PKC family of serine threonine kinases that regulate diverse signaling pathways. PKC zeta, encoded by PRKCZ, is an atypical isoform that does not require calcium or diacylglycerol and functions downstream of PI3K and PDK1, often within PAR polarity complexes and NF kappa B signaling, to control cell survival, polarity, migration, and metabolic responses. PKC gamma, encoded by PRKCG, is a conventional isoform that requires calcium, diacylglycerol, and phosphatidylserine for activation, is highly expressed in neurons, and contributes to synaptic plasticity, nociception, and cerebellar function. Germline mutations in PRKCG cause spinocerebellar ataxia type 14, while PRKCZ dysregulation has been linked to cancer signaling, insulin resistance, and inflammatory responses. Both isoforms are studied using phospho specific antibodies, kinase activity assays, genetic perturbation, and small molecule modulators; therapeutically, PKC pathway inhibitors and isoform selective probes are being explored to modulate neurological and oncogenic processes.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

篇参考文献 (0)

您是否在文献中引用过该产品？请点击下方按钮邮件告知我们。
引用该产品

生物信息学

蛋白别名: atypical protein kinase C; nPKC-y; nPKC-zeta; PKC gamma; PKC-gamma; PKC-y; PKC-Z; Protein kinase C gamma type; protein kinase C zeta subspecies; Protein kinase C zeta type; unnamed protein product

查看更多 收起

基因别名: AI098070; aPKCzeta; C80388; nPKC-zeta; PKC-gamma; PKC-ZETA; PKC2; PKCC; PKCG; PKCgamma; PKCI(3); Pkcz; Prkcc; PRKCG; PRKCZ; R74924; SCA14; zetaPKC

查看更多 收起

UniProt ID: (Human) P05129, (Human) Q05513, (Mouse) P63318, (Mouse) Q02956

查看更多 收起

Entrez Gene ID: (Human) 5582, (Human) 5590, (Mouse) 18752, (Mouse) 18762

查看更多 收起

功能
nucleotide binding protein kinase activity protein serine/threonine kinase activity protein kinase C activity calcium-dependent protein kinase C activity protein serine/threonine/tyrosine kinase activity protein binding ATP binding zinc ion binding kinase activity transferase activity metal ion binding protein serine kinase activity insulin receptor substrate binding transferase activity, transferring phosphorus-containing groups potassium channel regulator activity protein kinase binding protein domain specific binding phospholipase binding 14-3-3 protein binding non-receptor serine/threonine protein kinase
参与通路
phospholipase C-activating G-protein coupled receptor signaling pathway chemical synaptic transmission learning or memory chemosensory behavior response to toxic substance negative regulation of protein ubiquitination regulation of response to food positive regulation of mismatch repair intracellular signal transduction negative regulation of protein catabolic process regulation of circadian rhythm response to morphine negative regulation of neuron apoptotic process response to pain rhythmic process regulation of phagocytosis long-term synaptic potentiation innervation presynaptic modulation of chemical synaptic transmission synaptic signaling via neuropeptide negative regulation of proteasomal protein catabolic process response to angiotensin response to psychosocial stress regulation of synaptic vesicle exocytosis microtubule cytoskeleton organization protein phosphorylation inflammatory response signal transduction establishment of cell polarity negative regulation of protein complex assembly positive regulation of interleukin-10 production positive regulation of interleukin-13 production positive regulation of interleukin-4 production positive regulation of interleukin-5 production cellular response to insulin stimulus negative regulation of apoptotic process establishment or maintenance of epithelial cell apical/basal polarity positive regulation of T-helper 2 cell differentiation negative regulation of insulin receptor signaling pathway positive regulation of insulin receptor signaling pathway positive regulation of NF-kappaB transcription factor activity positive regulation of ERK1 and ERK2 cascade protein localization to plasma membrane neuron projection extension positive regulation of excitatory postsynaptic potential positive regulation of T-helper 2 cell cytokine production phosphorylation protein autophosphorylation positive regulation of cell-matrix adhesion cell surface receptor signaling pathway long-term memory positive regulation of cell proliferation insulin receptor signaling pathway cell migration peptidyl-serine phosphorylation actin cytoskeleton reorganization activation of phospholipase D activity activation of protein kinase B activity cellular protein localization positive regulation of glucose import vesicle transport along microtubule negative regulation of peptidyl-tyrosine phosphorylation positive regulation of synaptic transmission positive regulation of protein transport protein heterooligomerization negative regulation of hydrolase activity membrane depolarization membrane hyperpolarization protein kinase C signaling positive regulation of interleukin-5 secretion positive regulation of interleukin-13 secretion positive regulation of interleukin-10 secretion
guarantee_icon

性能保障

只要您发现Invitrogen抗体在实验中的表现与网站或说明书的所述内容不符，您即可享受免费退换货服务。*

了解更多
help_icon

随时为您服务

获取常见问题的专家解答，或者直接联系我们的技术专家，咨询应用、设备、常规产品使用问题。

联系技术支持