Invitrogen

Phospho-PKC zeta/lambda (Thr410, Thr403) Polyclonal Antibody

2 References
Datasheet
Protocols
Tech Support
Datasheet
Protocols
Tech Support

Product Details

PA5-17837

Applications
Tested Dilution
Publications

免疫印迹 (WB)

1:1,000
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产品规格

Species Reactivity

Human, Mouse, Non-human primate, Rat

Published species

Human

Host/Isotype

Rabbit / IgG

分类

Polyclonal

类型

Antibody

Immunogen

Synthetic phosphopeptide corresponding to residues surrounding pThr410 of human PKC zeta
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Conjugate

Unconjugated

形式

Liquid

纯化类型

Antigen affinity chromatography

保存液

0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol

内含物

no preservative

保存条件

-20°C

RRID

AB_10986758

Product Specific Information

It is not recommended to aliquot this antibody.

This antibody is not cross-reactive with endogenous levels of other PKC isoforms.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Bioinformatics

Protein Aliases: 14 - 3 - 3 - zeta isoform; atypical protein kinase C; nPKC-eta; nPKC-zeta; PKC-L; PRKCI; Protein kinase C eta type; protein kinase C zeta subspecies; Protein kinase C zeta type; protein kinase C, eta; protein kinase C, zeta; protein kinase C-eta

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Gene Aliases: 14-3-3-zetaisoform; AI098070; aPKCzeta; C80388; nPKC-eta; nPKC-zeta; PKC-L; PKC-ZETA; PKC2; Pkch; PKCL; Pkcz; PRKCH; PRKCL; PRKCZ; r14-3-3; R74924; zetaPKC

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UniProt ID: (Human) P24723, (Human) Q05513, (Mouse) P23298, (Rat) Q64617, (Rat) P09217, (Mouse) Q02956

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Entrez Gene ID: (Human) 5583, (Human) 5590, (Mouse) 18755, (Rat) 81749, (Rat) 25522, (Mouse) 18762

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Molecular Function: non-receptor serine/threonine protein kinase protein modifying enzyme

Function(s)
protein phosphorylation signal transduction positive regulation of macrophage derived foam cell differentiation peptidyl-serine phosphorylation platelet activation negative regulation of glial cell apoptotic process intracellular signal transduction positive regulation of keratinocyte differentiation positive regulation of B cell receptor signaling pathway positive regulation of NF-kappaB transcription factor activity positive regulation of glial cell proliferation protein kinase C signaling regulation of bicellular tight junction assembly microtubule cytoskeleton organization positive regulation of cell-matrix adhesion inflammatory response transforming growth factor beta receptor signaling pathway long-term memory positive regulation of cell proliferation insulin receptor signaling pathway cell migration establishment of cell polarity negative regulation of protein complex assembly actin cytoskeleton reorganization activation of phospholipase D activity activation of protein kinase B activity positive regulation of interleukin-4 production negative regulation of apoptotic process positive regulation of T-helper 2 cell differentiation positive regulation of glucose import negative regulation of insulin receptor signaling pathway positive regulation of insulin receptor signaling pathway vesicle transport along microtubule negative regulation of peptidyl-tyrosine phosphorylation protein heterooligomerization negative regulation of hydrolase activity membrane depolarization membrane hyperpolarization long-term synaptic potentiation positive regulation of ERK1 and ERK2 cascade protein localization to plasma membrane neuron projection extension positive regulation of excitatory postsynaptic potential positive regulation of T-helper 2 cell cytokine production positive regulation of interleukin-5 secretion positive regulation of interleukin-13 secretion positive regulation of interleukin-10 secretion phosphorylation cell differentiation cell surface receptor signaling pathway cellular response to insulin stimulus cellular protein localization positive regulation of synaptic transmission positive regulation of protein transport
Process(es)
protein kinase C activity calcium-independent protein kinase C activity ATP binding Ral GTPase binding enzyme binding metal ion binding protein kinase activity protein serine/threonine kinase activity protein binding potassium channel regulator activity protein kinase binding protein domain specific binding phospholipase binding insulin receptor substrate binding 14-3-3 protein binding nucleotide binding kinase activity transferase activity transferase activity, transferring phosphorus-containing groups
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