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Phospho-PKD2 (Ser812) Antibody (PA5-105830) in WB
Western blot analysis of Phospho-PKD2 (Ser812) in extracts from various samples. Samples were incubated with Phospho-PKD2 (Ser812) polyclonal antibody (Product # PA5-105830). Lane 1: Vero cells (serum starvation treatment), blocked with antigen-specific peptides; Lane 2: Vero cells (serum starvation treatment); Lane 3: B16f10 cells (serum starvation treatment).
产品信息
PA5-105830
产品规格
种属反应
Human,
Mouse,
Non-human primate,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human PKD2(Accession Q13563), corresponding to amino acid residues around phosphorylated Ser812.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
sequential chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2817229
产品详细信息
Antibody detects endogenous levels of PKD2 only when phosphorylated at Ser812.
靶标信息
This gene encodes a member of the polycystin protein family. The encoded protein contains multiple transmembrane domains, and cytoplasmic N- and C-termini. The protein may be an integral membrane protein involved in cell-cell/matrix interactions. The encoded protein may function in renal tubular development, morphology, and function, and may modulate intracellular calcium homoeostasis and other signal transduction pathways. This protein interacts with polycystin 1 to produce cation-permeable currents. Mutations in this gene have been associated with autosomal dominant polycystic kidney disease.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: A MGC138466; Autosomal dominant polycystic kidney disease type II protein; MGC138468; PC2; polycystic kidney disease 2 (autosomal dominant); polycystic kidney disease 2 homolog; Polycystic kidney disease 2 protein; Polycystic kidney disease 2 protein homolog; polycystin 2; Polycystin-2; Polycystwin; R48321; Transient receptor potential cation channel subfamily P member 2; transient receptor potential cation channel, subfamily P, member 2; TRPP1
基因别名: APKD2; C030034P18Rik; Pc-2; PC2; PKD2; PKD4; RGD1559992; TRPP2
UniProt ID: (Human) Q13563, (Mouse) O35245
Entrez Gene ID: (Human) 5311, (Rat) 498328, (Mouse) 18764
receptor binding
voltage-gated ion channel activity
voltage-gated calcium channel activity
voltage-gated sodium channel activity
potassium channel activity
calcium ion binding
protein binding
cytoskeletal protein binding
voltage-gated cation channel activity
identical protein binding
protein homodimerization activity
actinin binding
HLH domain binding
ion channel binding
calcium-induced calcium release activity
ATPase binding
phosphoprotein binding
muscle alpha-actinin binding
calcium channel activity
channel activity
alpha-actinin binding
metal ion binding
ion channel
branching involved in ureteric bud morphogenesis
liver development
embryonic placenta development
heart looping
detection of nodal flow
calcium ion transport
cell cycle arrest
JAK-STAT cascade
determination of left/right symmetry
heart development
negative regulation of cell proliferation
spinal cord development
neural tube development
regulation of cAMP metabolic process
positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle
cellular response to reactive oxygen species
metanephric part of ureteric bud development
sodium ion transmembrane transport
aorta development
regulation of cell proliferation
cytoplasmic sequestering of transcription factor
positive regulation of nitric oxide biosynthetic process
positive regulation of transcription from RNA polymerase II promoter
detection of mechanical stimulus
release of sequestered calcium ion into cytosol
centrosome duplication
regulation of postsynaptic membrane potential
negative regulation of ryanodine-sensitive calcium-release channel activity
placenta blood vessel development
renal tubule morphogenesis
renal artery morphogenesis
calcium ion transmembrane transport
positive regulation of cell cycle arrest
cellular response to hydrostatic pressure
cellular response to osmotic stress
cellular response to fluid shear stress
potassium ion transmembrane transport
determination of liver left/right asymmetry
metanephric mesenchyme development
mesonephric tubule development
mesonephric duct development
metanephric smooth muscle tissue development
metanephric cortex development
metanephric ascending thin limb development
metanephric cortical collecting duct development
metanephric distal tubule development
metanephric S-shaped body morphogenesis
regulation of calcium ion import
negative regulation of G1/S transition of mitotic cell cycle
kidney development
cellular calcium ion homeostasis
positive regulation of cytosolic calcium ion concentration
positive regulation of gene expression
transmembrane transport
renal system development
transport
ion transport
