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Invitrogen
Phospho-PTP1B / PTPN1 (Ser50) Polyclonal Antibody
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产品信息
PA5-35720
产品规格
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide derived from human PTP1B around the phosphorylation site of Serine 50
偶联物
形式
Liquid
浓度
Lot-Specific
保存条件
-20°C
运输条件
Ambient
RRID
产品详细信息
Concentration is lot-specific and will vary from 0.5-0.6 mg/ml
靶标信息
PTP1B (PTPN1) is a tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. It mediates dephosphorylation of EIF2AK3/PERK and in turn inactivates the protein kinase activity of EIF2AK3/PERK. PTP1B also plays a role in CKII- and p60c-src-induced signal transduction cascades. It regulates the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion. PTP1B also regulates the hepatocyte growth factor receptor signaling pathway through dephosphorylation of MET.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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