Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
应用 | 建议稀释比 | 已发表文章 |
---|---|---|
免疫印迹 (WB) |
1:500-1:1,000 | - |
产品规格 | |
---|---|
种属反应 |
Human, Mouse, Rat |
宿主/亚型 |
Rabbit / IgG |
分类 |
Polyclonal |
类型 |
Antibody |
抗原 |
A synthesized peptide derived from human PTP1B (Phospho-Tyr66) |
偶联物 |
Unconjugated |
形式 |
Liquid |
浓度 |
1 mg/mL |
纯化类型 |
Affinity chromatography |
保存液 |
PBS, pH 7.3, with 30% glycerol |
内含物 |
0.02% sodium azide |
保存条件 |
-20°C |
RRID |
AB_2662820 |
Phospho-PTP1B (Tyr66) Polyclonal Antibody detects endogenous levels of PTP1B only when phosphorylated at Tyr66.
PTP1B (PTPN1) is a tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. It mediates dephosphorylation of EIF2AK3/PERK and in turn inactivates the protein kinase activity of EIF2AK3/PERK. PTP1B also plays a role in CKII- and p60c-src-induced signal transduction cascades. It regulates the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion. PTP1B also regulates the hepatocyte growth factor receptor signaling pathway through dephosphorylation of MET.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: EC 3.1.3.48; hgnc9642; KIAA0283; protein tyrosine phosphatase, placental; protein-protein-tyrosine phosphatase HA2; Protein-tyrosine phosphatase 1B; Protein-tyrosine phosphatase HA2; PTN1; PTP-1B; PTP-HA2; RP5-1121H13.2; RPTPrho; tyrosine phosphatase 1b; tyrosine-phosphatase; Tyrosine-protein phosphatase non-receptor type 1
基因别名: Ptp; PTP-1B; PTP-HA2; PTP1B; PTPN1
UniProt ID: (Human) P18031, (Rat) P20417, (Mouse) P35821
Entrez Gene ID: (Human) 5770, (Rat) 24697, (Mouse) 19246
分子生物学功能:
protein phosphatase