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Phospho-PYK2 (Tyr402) Antibody (710087) in IHC (P)
Immunohistochemistry analysis of Phospho-FAK2 /PYK2 pTyr402 showing staining in the cytoplasm of paraffin-embedded human brain tissue (right) compared to a negative control without primary antibody (left). To expose target proteins, antigen retrieval was performed using 10 mM sodium citrate (pH 6.0), microwaved for 8-15 min. Following antigen retrieval, tissues were blocked in 3% H2O2-methanol for 15 min at... View More
产品信息
710087
产品规格
种属反应
Human
已发表种属
Not Applicable
宿主/亚型
Rabbit
/ IgG
Expression System
Expi293
分类
Recombinant Superclonal
类型
Antibody
克隆号
17HCLC
抗原
proprietary
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Protein A
保存液
PBS
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2532553
产品详细信息
This antibody is predicted to react with mouse based on sequence homology.
Recombinant rabbit polyclonal antibodies are unique offerings from Thermo Fisher Scientific. They are comprised of a selection of multiple different recombinant monoclonal antibodies, providing the best of both worlds - the sensitivity of polyclonal antibodies with the specificity of monoclonal antibodies - all delivered with the consistency only found in a recombinant antibody. While functionally the same as a polyclonal antibody - recognizing multiple epitope sites on the target and producing higher detection sensitivity for low abundance targets - a recombinant rabbit polyclonal antibody has a known mixture of light and heavy chains. The exact population can be produced in every lot, circumventing the biological variability typically associated with polyclonal antibody production.
靶标信息
PTK2B (FAK2) is a cytoplasmic tyrosine kinase involved in calcium-induced regulation of ion channels and activation of the map kinase signaling pathway. PTK2B regulates reorganization of the actin cytoskeleton, cell polarization, cell migration, adhesion, spreading, and bone remodeling. FAK2 plays a role in the regulation of the humoral immune response and is required for normal levels of marginal B-cells in the spleen and normal migration of splenic B-cells. It functions in signaling downstream of integrin and collagen receptors, immune receptors, G-protein coupled receptors, cytokine, chemokine, and growth factor receptors, and mediates responses to cellular stress. Aberrant FAK2 expression may play a role in cancer cell proliferation, migration, and invasion in tumor formation and metastasis. Elevated expression has been seen in gliomas, hepatocellular carcinoma, lung cancer, and breast cancer.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: CADTK; CAK-beta; Calcium-dependent tyrosine kinase; Calcium-regulated non-receptor proline-rich tyrosine kinase; Cell adhesion kinase beta; FADK; FADK 2; FAK; FAK1; Focal adhesion kinase 2; Proline-rich tyrosine kinase 2; protein kinase B; Protein-tyrosine kinase 2-beta; PTK2B protein tyrosine kinase 2 beta; RAFTK; Related adhesion focal tyrosine kinase
基因别名: CADTK; CAKB; FADK2; FAK2; PKB; PTK; PTK2B; PYK2; RAFTK
UniProt ID: (Human) Q14289
Entrez Gene ID: (Human) 2185
calmodulin-dependent protein kinase activity
protein tyrosine kinase activity
non-membrane spanning protein tyrosine kinase activity
signal transducer activity
NMDA glutamate receptor activity
receptor binding
protein binding
ATP binding
protein complex binding
3-phosphoinositide-dependent protein kinase binding
MAPK cascade
angiogenesis
oocyte maturation
response to hypoxia
positive regulation of cell-matrix adhesion
sprouting angiogenesis
adaptive immune response
marginal zone B cell differentiation
protein complex assembly
protein phosphorylation
apoptotic process
response to stress
cellular defense response
response to osmotic stress
signal transduction
cell surface receptor signaling pathway
signal complex assembly
epidermal growth factor receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
integrin-mediated signaling pathway
positive regulation of cell proliferation
negative regulation of cell proliferation
regulation of cell shape
response to mechanical stimulus
response to hormone
response to glucose
response to lithium ion
positive regulation of endothelial cell migration
negative regulation of muscle cell apoptotic process
regulation of cGMP-mediated signaling
regulation of macrophage chemotaxis
positive regulation of neuron projection development
glial cell proliferation
peptidyl-tyrosine phosphorylation
regulation of cell adhesion
positive regulation of cell growth
positive regulation of cell migration
negative regulation of bone mineralization
regulation of cGMP biosynthetic process
positive regulation of actin filament polymerization
neuron projection development
regulation of inositol trisphosphate biosynthetic process
tumor necrosis factor-mediated signaling pathway
ionotropic glutamate receptor signaling pathway
response to immobilization stress
peptidyl-tyrosine autophosphorylation
response to cocaine
response to drug
response to hydrogen peroxide
activation of Janus kinase activity
negative regulation of apoptotic process
stress fiber assembly
negative regulation of potassium ion transport
positive regulation of JUN kinase activity
negative regulation of neuron apoptotic process
blood vessel endothelial cell migration
positive regulation of phosphatidylinositol 3-kinase activity
innate immune response
positive regulation of nitric oxide biosynthetic process
bone resorption
response to ethanol
negative regulation of myeloid cell differentiation
positive regulation of translation
positive regulation of angiogenesis
positive regulation of protein kinase activity
positive regulation of JNK cascade
protein autophosphorylation
vascular endothelial growth factor receptor signaling pathway
focal adhesion assembly
positive regulation of peptidyl-tyrosine phosphorylation
regulation of calcium-mediated signaling
positive regulation of nitric-oxide synthase activity
regulation of release of sequestered calcium ion into cytosol
response to cAMP
response to calcium ion
positive regulation of synaptic transmission, glutamatergic
long-term synaptic potentiation
long term synaptic depression
chemokine-mediated signaling pathway
positive regulation of ERK1 and ERK2 cascade
cellular response to retinoic acid
cellular response to fluid shear stress
activation of GTPase activity
regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
regulation of establishment of cell polarity
regulation of actin cytoskeleton reorganization
regulation of N-methyl-D-aspartate selective glutamate receptor activity
positive regulation of excitatory postsynaptic potential
positive regulation of B cell chemotaxis
positive regulation of DNA biosynthetic process
