Invitrogen

Phospho-Progesterone Receptor (Ser345) Polyclonal Antibody

产品信息

PA5-64704

应用	建议稀释比	已发表文章
免疫印迹 (WB)	1:1,000	-

产品规格
种属反应	Human
宿主/亚型	Rabbit / IgG
分类	Polyclonal
类型	Antibody
抗原	A synthesized peptide derived from human Progesterone Receptor (Phospho-Ser345) 查看免疫原
偶联物	Unconjugated
形式	Liquid
浓度	1 mg/mL
纯化类型	Affinity chromatography
保存液	PBS, pH 7.4, with 50% glycerol
内含物	0.02% sodium azide
保存条件	-20°C
RRID	AB_2662406

产品详细信息

Phospho-Progesterone Receptor (Ser345) Polyclonal Antibody detects endogenous levels of Progesterone Receptor only when phosphorylated at Ser345.

靶标信息

The progesterone receptor (PR) is a member of the steroid family of nuclear receptors. The PR mediates the physiological effects of progesterone, which plays a central role in reproductive events associated with the establishment and maintenance of pregnancy. PR is found as a 94 kDa protein (Form A) or a 120 kDa protein (Form B) due to the use of alternative translation initiation sites. PR-B is the transcriptionally active form and is responsible for activating genes for the maintenance of the endometrium, maintenance of pregnancy, and inhibition of ovulation. PR-A is identical to PR-B except for a 165 amino acid deletion at the N-terminus. This deletion exposes a 140 amino acid inhibitory domain (ID) that acts as a repressor of steroid hormone transcriptional activity. In its inactive state, PgR forms a multiprotein complex which includes heat shock proteins and immunophins. Upon binding of progesterone hormone to its receptor, there is a conformational change that allows dimerization and binding of the receptor to progesterone response elements (PRE) sequences, resulting in activated transcription. A Null mutation in the PGR gene leads to pleiotrophic reproductive abnormalities.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: Nuclear receptor subfamily 3 group C member 3; PR; Progesterone receptor

基因别名: NR3C3; PGR; PR

UniProt ID: (Human) P06401

Entrez Gene ID: (Human) 5241

功能

transcription initiation from RNA polymerase II promoter signal transduction cell-cell signaling negative regulation of gene expression steroid hormone mediated signaling pathway positive regulation of transcription from RNA polymerase II promoter

参与通路

RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding DNA binding steroid hormone receptor activity steroid binding protein binding zinc ion binding enzyme binding ATPase binding

Phospho-Progesterone Receptor (Ser345) Polyclonal Antibody

产品信息

PA5-64704

免疫印迹 (WB)

种属反应

宿主/亚型

分类

类型

抗原

偶联物

形式

浓度

纯化类型

保存液

内含物

保存条件

RRID

产品详细信息

靶标信息

篇参考文献 (0)

生物信息学

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