Search Thermo Fisher Scientific
图: 1 / 4
Antibody detects endogenous levels of RAD17 only when phosphorylated at Ser359.
Rad17 is essential for sustained cell growth, maintenance of chromosomal stability, and ATR-dependent checkpoint activation upon DNA damage. It has a weak ATPase activity required for binding to chromatin. Rad17 also participates in the recruitment of the RAD1-RAD9-HUS1 complex and RHNO1 onto chromatin, and in CHEK1 activation. May also serve as a sensor of DNA replication progression, and may be involved in homologous recombination.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: cell cycle checkpoint protein (RAD17); Cell cycle checkpoint protein RAD17; FLJ41520; hRad17; RAD1 homolog; RAD17 (Ser647); RAD17 homolog; Rad17 like protein; Rad17-like protein; RF-C activator 1 homolog; RF-C/activator 1 homolog
基因别名: CCYC; HRAD17; MmRad24; R24L; RAD17; RAD17SP; RAD24
UniProt ID: (Human) O75943, (Mouse) Q6NXW6
Entrez Gene ID: (Human) 5884, (Rat) 310034, (Mouse) 19356