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Invitrogen
Phospho-RAD17 (Ser656) Recombinant Superclonal Antibody (1HCLC)
高级验证
This Antibody was verified by Cell treatment to ensure that the antibody binds to the antigen stated.
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Phospho-RAD17 (Ser656) Antibody (711120) in WB
Western blot analysis was performed on Whole cell extracts (30 µg lysate) of HeLa (Lane 1), HeLa treated with Etoposide (100 µM/mL for 2hr) (Lane 2), K-562 (Lane 3) and K-562 treated with Etoposide (100 µM/mL for 2hr) (Lane 4). The blots were probed with Anti-Rad17 (pS656) Recombinant Rabbit Polyclonal Antibody (Product # 711120, 1-2 µg/mL) and detected by chemiluminescence using Goat anti-Rabbit IgG (Heavy... View More
产品信息
711120
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
Expression System
Expi293
分类
Recombinant Superclonal
类型
Antibody
克隆号
1HCLC
抗原
Peptide corresponding to Human RAD17 (aa 653-660)
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.2
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2632995
产品详细信息
This antibody is predicted to react with Monkey, Sheep and Bovine
Recombinant rabbit polyclonal antibodies are unique offerings from Thermo Fisher Scientific. They are comprised of a selection of multiple different recombinant monoclonal antibodies, providing the best of both worlds - the sensitivity of polyclonal antibodies with the specificity of monoclonal antibodies - all delivered with the consistency only found in a recombinant antibody. While functionally the same as a polyclonal antibody - recognizing multiple epitope sites on the target and producing higher detection sensitivity for low abundance targets - a recombinant rabbit polyclonal antibody has a known mixture of light and heavy chains. The exact population can be produced in every lot, circumventing the biological variability typically associated with polyclonal antibody production.
靶标信息
Rad17 is essential for sustained cell growth, maintenance of chromosomal stability, and ATR-dependent checkpoint activation upon DNA damage. It has a weak ATPase activity required for binding to chromatin. Rad17 also participates in the recruitment of the RAD1-RAD9-HUS1 complex and RHNO1 onto chromatin, and in CHEK1 activation. May also serve as a sensor of DNA replication progression, and may be involved in homologous recombination.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: cell cycle checkpoint protein (RAD17); Cell cycle checkpoint protein RAD17; FLJ41520; hRad17; RAD1 homolog; RAD17 (Ser647); RAD17 homolog; Rad17 like protein; Rad17-like protein; RF-C activator 1 homolog; RF-C/activator 1 homolog
基因别名: CCYC; HRAD17; R24L; RAD17; RAD17SP; RAD24
UniProt ID: (Human) O75943
Entrez Gene ID: (Human) 5884
