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产品信息
PA5-64808
| 应用 | 建议稀释比 | 已发表文章 |
|---|---|---|
免疫印迹 (WB) |
1:1,000 | - |
| 产品规格 | |
|---|---|
种属反应 |
Human, Mouse |
宿主/亚型 |
Rabbit / IgG |
分类 |
Polyclonal |
类型 |
Antibody |
抗原 |
A synthesized peptide derived from human ROR2 (Phospho-Ser449) |
偶联物 |
Unconjugated |
形式 |
Liquid |
浓度 |
1 mg/mL |
纯化类型 |
Affinity chromatography |
保存液 |
PBS, pH 7.4, with 50% glycerol |
内含物 |
0.02% sodium azide |
保存条件 |
-20°C |
RRID |
AB_2665304 |
产品详细信息
Phospho-ROR2 (Ser449) Polyclonal Antibody detects endogenous levels of ROR2 only when phosphorylated at Ser449.
靶标信息
ROR2 is a tyrosine-protein kinase receptor which may be involved in the early formation of the chondrocytes. It seems to be required for cartilage and growth plate development. This Type I membrane protein is expressed at high levels during early embryonic development. The expression levels drop strongly around day 16 and there are only very low levels in adult tissues. Defects in ROR2 are a cause of brachydactyly type B1 (BDB1). BDB1 is an autosomal dominant skeletal disorder characterized by hypoplasia/aplasia of distal phalanges and nails. In BDB1 the middle phalanges are short but in addition the terminal phalanges are rudimentary or absent. Both fingers and toes are affected. The thumbs and big toes are usually deformed. Defects in ROR2 are a cause of recessive Robinow syndrome (RRS). RRS is an autosomal disorder characterized by skeletal dysplasia with generalized limb bone shortening, segmental defects of the spine, brachydactyly and a dysmorphic facial appearance. The protein contains 1 frizzled (FZ) domain, 1 immunoglobulin-like C2-type domain, and 1 kringle domain.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: neurotrophic tyrosine kinase receptor-related 2; neurotrophic tyrosine kinase, receptor related 2; Neurotrophic tyrosine kinase, receptor-related 2; receptor tyrosine kinase-like orphan receptor 2; Tyrosine-protein kinase transmembrane receptor ROR2
基因别名: BDB; BDB1; mRor2; NTRKR2; ROR2
UniProt ID: (Human) Q01974
Entrez Gene ID: (Human) 4920, (Mouse) 26564
分子生物学功能:
transmembrane signal receptor
cartilage condensation
somitogenesis
signal transduction
transmembrane receptor protein tyrosine kinase signaling pathway
Wnt signaling pathway, calcium modulating pathway
smoothened signaling pathway
JNK cascade
multicellular organism development
negative regulation of cell proliferation
peptidyl-tyrosine phosphorylation
positive regulation of cell migration
BMP signaling pathway
embryonic genitalia morphogenesis
inner ear morphogenesis
embryonic digit morphogenesis
cell fate commitment
positive regulation of transcription, DNA-templated
Wnt signaling pathway, planar cell polarity pathway
SMAD protein signal transduction
negative regulation of canonical Wnt signaling pathway
positive regulation of canonical Wnt signaling pathway
skeletal system development
protein phosphorylation
phosphorylation
cell differentiation
regulation of canonical Wnt signaling pathway
transmembrane receptor protein tyrosine kinase activity
frizzled binding
protein binding
ATP binding
Wnt-protein binding
metal ion binding
coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway
nucleotide binding
protein kinase activity
protein tyrosine kinase activity
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
