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Invitrogen
Phospho-RSK1/RSK2 (Ser380, Ser386) Recombinant Rabbit Monoclonal Antibody (HL3818)
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Phospho-RSK1/RSK2 (Ser380, Ser386) Antibody (MA573864) in WB
Western blot analysis of Phospho-RSK1/RSK2 (Ser380, Ser386) in Untreated (–) and treated (+) NIH-3T3 whole cell extracts (30 µg). Samples were separated with 7.5% SDS-PAGE, incubated with Phospho-RSK1/RSK2 (Ser380, Ser386) Recombinant Monoclonal antibody (Product # MA573864) at a dilution of 1:1,000 and detected with HRP-conjugated anti-rabbit IgG antibody.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
MA573864
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
HL3818
抗原
Carrier-protein conjugated synthetic peptide surrounding phospho Ser380 of human p90 RSK1. The exact sequence is proprietary.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Protein A
保存液
PBS
内含物
no preservative
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
RSK1 (Ribosomal S6 Kinase 1) and RSK2 (Ribosomal S6 Kinase 2) are genes that encode members of the RSK family of serine/threonine kinases, which are downstream effectors of the extracellular signal-regulated kinase (ERK) signaling pathway. These kinases play critical roles in regulating various cellular processes, including growth, proliferation, survival, and differentiation. RSK1 and RSK2 are activated by phosphorylation in response to extracellular signals such as growth factors, hormones, and mitogens. Once activated, they phosphorylate a range of substrates, including transcription factors, ribosomal proteins, and other kinases, thereby influencing gene expression and protein synthesis. Dysregulation of RSK1 and RSK2 activity has been implicated in several pathological conditions, including cancer, where they can promote tumor growth and survival, and neurodevelopmental disorders, such as Coffin-Lowry syndrome, which is associated with mutations in the RSK2 gene. Understanding the function and regulation of RSK1 and RSK2 is essential for developing targeted therapies aimed at modulating their activity in disease contexts. Research into these kinases provides valuable insights into the broader mechanisms of ERK signaling and its impact on cellular physiology and disease progression.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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