Invitrogen

Phospho-SHP-1 (Tyr564) Polyclonal Antibody

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说明书
实验方案
问题与答案
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说明书
实验方案
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技术支持
Phospho-SHP-1 (Tyr564) Polyclonal Antibody

产品信息

PA5-97397

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:500-1:2,000
-

酶联免疫吸附实验 (ELISA)

1 µg/mL
-
产品规格

种属反应

Human, Mouse

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

A synthetic phosphorylated peptide around Y564 of human PTPN6 (NP_0028222)
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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1.14 mg/mL

纯化类型

Affinity Chromatography

保存液

PBS, pH 7.3, with 50% glycerol

内含物

0.01% thimerosal

保存条件

-20°C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2809199

产品详细信息

Immunogen sequence: DVYEN; Positive Samples: HeLa, RAW 264.7; Cellular Location: Cytoplasm, Nucleus

靶标信息

SHP-1 (PTPN6) is a non-receptor protein tyrosine phosphatase that is expressed primarily in hematopoietic cells. The enzyme is composed of two SH2 domains, a tyrosine phosphatase catalytic domain, and a carboxy-terminal regulatory domain. SHP-1 removes phosphates from target proteins to downregulate several tyrosine kinase-regulated pathways. In hematopoietic cells, the amino-terminal SH2 domain of SHP-1 binds to tyrosine phosphorylated erythropoietin receptors (EpoR) to negatively regulate hematopoietic growth. Overexpression of SHP-1 in epithelial cells results in dephosphorylation of the Ros receptor tyrosine kinase and subsequent downregulation of Ros-dependent cell proliferation and transformation. Following ligand binding in myeloid cells, SHP-1 associates with the IL-3R beta chain and downregulates IL-3-induced tyrosine phosphorylation and cell proliferation.

⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: 70Z-SHP; EC 3.1.3.48; hematopoietic cell phosphatase; Hematopoietic cell protein-tyrosine phosphatase; motheaten; Protein-tyrosine phosphatase 1C; Protein-tyrosine phosphatase SHP-1; PTN6; PTP-1C; PTPTY-42; SH-PTP1; SHP-1; Tyrosine-protein phosphatase non-receptor type 6

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基因别名: 70Z-SHP; HCP; HCPH; HPTP1C; me; PTP-1C; PTP1C; PTPN6; PTPTY-42; SH-PTP1; SHP-1; SHP-1L; SHP1

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UniProt ID: (Human) P29350, (Mouse) P29351

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Entrez Gene ID: (Human) 5777, (Mouse) 15170

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功能
phosphotyrosine binding protein tyrosine phosphatase activity transmembrane receptor protein tyrosine phosphatase activity protein binding SH3 domain binding protein kinase binding SH2 domain binding phosphoprotein phosphatase activity hydrolase activity phosphatase activity natural killer cell lectin-like receptor binding protein phosphatase
参与通路
hematopoietic progenitor cell differentiation negative regulation of humoral immune response mediated by circulating immunoglobulin protein dephosphorylation apoptotic process G-protein coupled receptor signaling pathway cell proliferation positive regulation of cell proliferation negative regulation of cell proliferation positive regulation of phosphatidylinositol 3-kinase signaling peptidyl-tyrosine phosphorylation cell differentiation platelet activation platelet formation T cell costimulation abortive mitotic cell cycle positive regulation of cell adhesion mediated by integrin peptidyl-tyrosine dephosphorylation intracellular signal transduction megakaryocyte development negative regulation of T cell proliferation natural killer cell mediated cytotoxicity negative regulation of MAP kinase activity regulation of B cell differentiation negative regulation of peptidyl-tyrosine phosphorylation B cell receptor signaling pathway negative regulation of B cell receptor signaling pathway negative regulation of T cell receptor signaling pathway leukocyte migration regulation of release of sequestered calcium ion into cytosol regulation of type I interferon-mediated signaling pathway regulation of ERK1 and ERK2 cascade platelet aggregation regulation of G1/S transition of mitotic cell cycle signal transduction dephosphorylation cytokine-mediated signaling pathway negative regulation of MAPK cascade
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