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Invitrogen
Phospho-SHP-2 (Tyr580) Polyclonal Antibody
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产品信息
PA5-35580
产品规格
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide derived from human SHP-2 around the phosphorylation site of Tyrosine 580
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
Lot-Specific
保存条件
-20°C
运输条件
Ambient
RRID
产品详细信息
Concentration is lot-specific and will vary from 0.5-0.6 mg/ml
靶标信息
SHP-2 (Src homology-2 domain containing protein) is a member of the protein tyrosine phosphatase (PTP) family, a protein family that contains signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. SHP-2 contains two tandem Src homology-2 (SH2) domains, which function as phosphotyrosine binding domains either directly or through scaffolding intermediates such as the insulin-receptor substrate 1 (IRS-1). These SH2 domains mediate the interaction of SHP-2 with its substrates, allowing SHP-2 to dephosphorylate proteins that inhibit signaling kinases such as ERK1 and AKT. SHP-2 is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in SHP-2 are a cause of Noonan syndrome as well as acute myeloid leukemia. Two transcript variants encoding different isoforms of SHP-2 have been found.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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