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Invitrogen
Phospho-SHP2 (Ser576) Polyclonal Antibody
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Phospho-SHP2 (Ser576) Antibody (44-557G) in ICC/IF
Immunofluorescence analysis of Phospho-SHP-2/PTPN11 pSer576 was done on 70% confluent log phase NIH/3T3 cells. The cells were fixed with 4% paraformaldehyde for 10 minutes, permeabilized with 0.1% Triton™ X-100 for 10 minutes, and blocked with 1% BSA for 1 hour at room temperature. The cells were labeled with Phospho-SHP-2/PTPN11 pSer576 Rabbit Polyclonal Antibody (Product # 44-557G) at 1:250 dilution in 0.... View More
产品信息
44-557G
产品规格
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
The antiserum was produced against a chemically synthesized phosphopeptide derived from the region of human SHP2 that contains serine 576. The sequence is conserved in mouse, rat and chicken.
偶联物
形式
Liquid
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
靶标信息
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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