The Hedgehog signaling pathway plays an important role in early human development. The pathway is a signaling cascade that plays a role in pattern formation and cellular proliferation during development. This gene encodes a negative regulator of the hedgehog signaling pathway. Defects in this gene are a cause of medulloblastoma. Alternative splicing results in multiple transcript variants.
蛋白别名: OTTHUMP00000020377; OTTHUMP00000020378; OTTHUMP00000020379; RP11-47A8.1; SUFUH; Suppressor of fused homolog
基因别名: PRO1280; SUFU; SUFUH; SUFUXL; UNQ650/PRO1280
UniProt ID: (Human) Q9UMX1
Entrez Gene ID: (Human) 51684
分子生物学功能: scaffold/adaptor protein