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Invitrogen
Phospho-(Ser/Thr) ATM + ATR Substrate Polyclonal Antibody
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Phospho-(Ser/Thr) ATM + ATR Substrate Antibody (PA5-117231) in WB
Western blot analysis of Phospho-(Ser/Thr) ATM + ATR Substrate in extracts of various cell lines. Samples were incubated with Phospho-(Ser/Thr) ATM + ATR Substrate Polyclonal antibody (Product # PA5-117231) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) secondary antibody at a dilution of 1:10,000. Jurkat and NIH/3T3 cells were treated by Calyculin A (100 nM) at 37°C for 30 minutes ... View More
产品信息
PA5-117231
产品规格
种属反应
All
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide corresponding to a sequence containing phosphorylated S & T
偶联物
形式
Liquid
浓度
1.65 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.01% thimerosal
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Positive Samples: Jurkat, NIH/3T3, C6
靶标信息
Ataxia telangiectasia mutated kinase (ATM) and ataxia telangiectasia and Rad3-related kinase (ATR) are related kinases that regulate cell cycle checkpoints and DNA repair. The identified substrates for ATM are p53, p95/NBS1, MDM2, Chk2, BRCA1, CtIP, 4E-BP1, and Chk1. The essential requirement for the substrates of ATM/ATR is S*/T*Q. Hydrophobic amino acids at positions -3 and -1, and negatively charged amino acids at position +1 are positive determinants for substrate recognition by these kinases. Positively charged residues surrounding the S*/T*Q are negative determinants for substrate phosphorylation. The complex phenotype of AT cells suggests that it likely has additional substrates.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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