Invitrogen

Phospho-TEK (Ser1119) Polyclonal Antibody

查看其他48个TIE2 (TEK)抗体

产品信息

PA5-64613

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:1,000

-

产品规格

种属反应

Human, Mouse

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

A synthesized peptide derived from human TIE2 (Phospho-Ser1119)

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Affinity chromatography

保存液

PBS, pH 7.4, with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20°C

运输条件

Wet ice

RRID

AB_2663142

产品详细信息

Phospho-TEK (Ser1119) Polyclonal Antibody detects endogenous levels of TEK only when phosphorylated at Ser1119.

靶标信息

The TEK receptor tyrosine kinase is expressed almost exclusively in endothelial cells. TEK signaling appears to be critical for endothelial cell-smooth muscle cell communication in venous morphogenesis, and defects in TEK are associated with inherited venous malformations. The ligand angiopoietin-1 binds to this receptor and mediates a signaling pathway that functions in embryonic vascular development. Immunoblotting showed that TIE2 expression was increased by thyroid-stimulating hormone and agents that increased intracellular cAMP. HSCs expressing the receptor tyrosine kinase TIE2 are quiescent and antiapoptotic and comprise a side population of HSCs that adhere to osteoblasts in the bone marrow niche.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: Angiopoietin-1 receptor; CD202b; CD202b antigen; EC 2.7.10; EC 2.7.10.1; Endothelial tyrosine kinase; hTIE2; HYK; mTIE2; p140 TEK; STK1; TEK tyrosine kinase, endothelial; TEKT1; Tunica interna endothelial cell kinase; Tyrosine kinase with Ig and EGF homology domains-2; Tyrosine-protein kinase receptor TEK; Tyrosine-protein kinase receptor TIE-2

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基因别名: AA517024; CD202B; Hyk; STK1; TEK; TIE-2; TIE2; VMCM; VMCM1

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UniProt ID: (Human) Q02763, (Mouse) Q02858

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Entrez Gene ID: (Human) 7010, (Mouse) 21687

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protein kinase activity protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity receptor activity Ras guanyl-nucleotide exchange factor activity protein binding ATP binding growth factor binding nucleotide binding kinase activity transferase activity transferase activity, transferring phosphorus-containing groups transmembrane signal receptor

参与通路

MAPK cascade angiogenesis response to hypoxia positive regulation of protein phosphorylation endothelial cell proliferation positive regulation of endothelial cell proliferation endochondral ossification sprouting angiogenesis signal transduction transmembrane receptor protein tyrosine kinase signaling pathway cell-cell signaling heart development positive regulation of endothelial cell migration positive regulation of phosphatidylinositol 3-kinase signaling negative regulation of angiogenesis peptidyl-tyrosine phosphorylation organ regeneration regulation of establishment or maintenance of cell polarity substrate adhesion-dependent cell spreading negative regulation of apoptotic process regulation of vascular permeability response to peptide hormone positive regulation of GTPase activity positive regulation of phosphatidylinositol 3-kinase activity response to estrogen positive regulation of angiogenesis protein autophosphorylation Tie signaling pathway negative regulation of inflammatory response leukocyte migration protein oligomerization response to cAMP positive regulation of focal adhesion assembly positive regulation of protein kinase B signaling definitive hemopoiesis heart trabecula formation positive regulation of ERK1 and ERK2 cascade positive regulation of intracellular signal transduction positive regulation of actin cytoskeleton reorganization regulation of endothelial cell apoptotic process negative regulation of endothelial cell apoptotic process patterning of blood vessels vasculogenesis regulation of endothelial cell proliferation positive regulation of cytokine secretion involved in immune response protein phosphorylation cell-matrix adhesion phosphorylation single organismal cell-cell adhesion hemopoiesis regulation of cell migration positive regulation of vascular endothelial growth factor receptor signaling pathway response to retinoic acid positive regulation of peptidyl-serine phosphorylation intracellular signal transduction positive regulation of protein import into nucleus regulation of angiogenesis positive regulation of cell adhesion regulation of NIK/NF-kappaB signaling