Bioss

Phospho-TIF1 beta (Ser824) Polyclonal Antibody

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说明书
实验方案
问题与答案
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说明书
实验方案
问题与答案
技术支持
Phospho-TIF1 beta (Ser824) Polyclonal Antibody

产品信息

BS-3423R

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:500-1:2,000
-

免疫组化（石蜡） (IHC (P))

1:200
-

免疫组化（冰冻） (IHC (F))

1:100-1:500
-

免疫细胞化学 (ICC/IF)

1:50-1:200
-

流式细胞分析 (Flow)

1:20-1:100
-

酶联免疫吸附实验 (ELISA)

1:500-1:1,000
-
产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

KLH conjugated synthetic phosphopeptide derived from human TIF1 beta around the phosphorylation site of Ser824.
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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Protein A

保存液

0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA

内含物

0.02% ProClin 300

保存条件

-20°C

运输条件

Ambient (domestic); Wet ice (international)

靶标信息

Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression. Recruitment of SETDB1 induces heterochromatinization. May play a role as a coactivator for CEBPB and NR3C1 in the transcriptional activation of ORM1. Also corepressor for ERBB4. Inhibits E2F1 activity by stimulating E2F1-HDAC1 complex formation and inhibiting E2F1 acetylation. May serve as a partial backup to prevent E2F1-mediated apoptosis in the absence of RB1. Important regulator of CDKN1A/p21(CIP1). Has E3 SUMO-protein ligase activity toward itself via its PHD-type zinc finger. Also specifically sumoylates IRF7, thereby inhibiting its transactivation activity. Ubiquitinates p53/TP53 leading to its proteosomal degradation; the function is enhanced by MAGEC2 and MAGEA2, and possibly MAGEA3 and MAGEA6. Mediates the nuclear localization of KOX1, ZNF268 and ZNF300 transcription factors.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: E3 SUMO-protein ligase TRIM28; KAP-1; KRAB [Kruppel-associated box domain]-associated protein 1; KRAB-A-interacting protein; KRAB-associated protein 1; KRAB-interacting protein 1; KRIP-1; Nuclear corepressor KAP-1; protein phosphatase 1, regulatory subunit 157; RING finger protein 96; RING-type E3 ubiquitin transferase TIF1-beta; TIF1-beta; Transcription intermediary factor 1-beta; transcriptional intermediary factor 1, beta; transcriptional intermediary factor 1-beta; tripartite motif protein 28; Tripartite motif-containing protein 28

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基因别名: AA408787; KAP-1; KAP1; KRIP-1; Krip1; MommeD9; PPP1R157; RNF96; TF1B; TIF1B; Tif1beta; TRIM28

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UniProt ID: (Human) Q13263, (Mouse) Q62318, (Rat) O08629

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Entrez Gene ID: (Human) 10155, (Mouse) 21849, (Rat) 116698

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功能
RNA polymerase II transcription coactivator activity DNA binding chromatin binding transcription factor activity, sequence-specific DNA binding transcription corepressor activity protein kinase activity ubiquitin-protein transferase activity protein binding zinc ion binding ligase activity ubiquitin protein ligase binding Krueppel-associated box domain binding sequence-specific DNA binding poly(A) RNA binding chromo shadow domain binding promoter-specific chromatin binding transcription coactivator activity UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity ribosomal S6-glutamic acid ligase activity coenzyme F420-0 gamma-glutamyl ligase activity coenzyme F420-2 alpha-glutamyl ligase activity metal ion binding protein-glycine ligase activity protein-glycine ligase activity, initiating protein-glycine ligase activity, elongating tubulin-glycine ligase activity protein-glutamic acid ligase activity tubulin-glutamic acid ligase activity
参与通路
negative regulation of transcription from RNA polymerase II promoter in utero embryonic development epithelial to mesenchymal transition DNA repair transcription, DNA-templated regulation of transcription, DNA-templated protein phosphorylation embryo implantation protein ubiquitination protein sumoylation positive regulation of transcription factor import into nucleus DNA methylation involved in embryo development innate immune response positive regulation of DNA repair negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated protein autophosphorylation protein oligomerization convergent extension involved in axis elongation embryonic placenta morphogenesis negative regulation of DNA demethylation negative regulation of viral release from host cell regulation of genetic imprinting transcription initiation from RNA polymerase II promoter Ras protein signal transduction covalent chromatin modification positive regulation of transcription from RNA polymerase II promoter positive regulation of methylation-dependent chromatin silencing
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