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Invitrogen
Phospho-alpha Synuclein (Tyr136) Polyclonal Antibody
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Phospho-alpha Synuclein (Tyr136) Antibody (PA5-35661) in WB
Western blot analysis of Phospho-alpha Synuclein pTyr136 in mouse brain tissue lysates with a blocking peptide (lane 1) and no blocking peptide (lane 2) using a Phospho-alpha Synuclein pTyr136 polyclonal antibody (Product # PA5-35661).
产品信息
PA5-35661
产品规格
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide derived from human Synuclein- alpha around the phosphorylation site of Tyrosine 136
偶联物
形式
Liquid
浓度
Lot-Specific
保存条件
-20°C
运输条件
Ambient
RRID
产品详细信息
Concentration is lot-specific and will vary from 0.5-0.6 mg/ml
靶标信息
Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. These proteins are abundant in the brain and play a role in regulating synaptic transmission and membrane trafficking. Alpha- and beta-synuclein have been shown to selectively inhibit phospholipase D2, suggesting that they may also be involved in signaling pathways. Defects in the SNCA gene, which encodes alpha-synuclein, have been implicated in the pathogenesis of Parkinson's disease. Additionally, alpha-synuclein peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Multiple alternatively spliced transcripts encoding different isoforms have been identified for this gene. Diseases associated with SNCA include Parkinson Disease 1, Autosomal Dominant and Dementia, Lewy Body.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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