Invitrogen

Phospho-c-Abl (Tyr393) Recombinant Superclonal Antibody (19HCLC)

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说明书
实验方案
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产品信息

711366

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1-2 µg/mL
-

免疫细胞化学 (ICC/IF)

2 µg/mL
-

流式细胞分析 (Flow)

5 µg/1x10^6 cells
-
产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

Expression System

Expi293

分类

Recombinant Superclonal

类型

Antibody

克隆号

19HCLC

抗原

Peptide corresponding to Human ABL1 (aa 390-397)
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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.5 mg/mL

纯化类型

Protein A

保存液

PBS, pH 7.2

内含物

0.09% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Wet ice

RRID

AB_2632967

产品详细信息

This antibody is predicted to react with Monkey, Pig and Mouse.

Recombinant rabbit polyclonal antibodies are unique offerings from Thermo Fisher Scientific. They are comprised of a selection of multiple different recombinant monoclonal antibodies, providing the best of both worlds - the sensitivity of polyclonal antibodies with the specificity of monoclonal antibodies - all delivered with the consistency only found in a recombinant antibody. While functionally the same as a polyclonal antibody - recognizing multiple epitope sites on the target and producing higher detection sensitivity for low abundance targets - a recombinant rabbit polyclonal antibody has a known mixture of light and heavy chains. The exact population can be produced in every lot, circumventing the biological variability typically associated with polyclonal antibody production.

靶标信息

The ABL1 proto-oncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response. Activity of c-Abl protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns c-Abl into an oncogene. The DNA-binding activity of the ubiquitously expressed ABL1 tyrosine kinase is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function for c-Abl. In chronic myelogenous leukemia and a subset of acute lymphoblastic leukemias, the c-Abl proto oncogene undergoes a (9;22) chromosomal translocation producing a novel rearranged chromosome (the Philadelphia chromosome). As the result of the fusion of c-Abl sequences from chromosome 9 to the Bcr gene on chromosome 22. The c-Abl oncogene was initially identified as the viral transforming gene of Abelson murine leukemia virus (A-MuLV). c-ABL potentially regulates DNA repair by activating the proapoptotic pathway when the DNA damage is too severe to be repaired.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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生物信息学

蛋白别名: Abelson murine leukemia oncogene; Abelson murine leukemia viral (v-abl) oncogene homolog 1; Abelson murine leukemia viral oncogene homolog 1; Abelson tyrosine-protein kinase 1; Abl 1 antib; ABL2; ABLL; ARG; B30; bcr/c-abl oncogene protein; c-abl oncogene 1, non-receptor tyrosine kinase; c-abl oncogene 1, receptor tyrosine kinase; p150; Proto-oncogene c-Abl; proto-oncogene tyrosine-protein kinase ABL1; RP11-83J21.1; Tyrosine kinase ARG; Tyrosine-protein kinase ABL1; v-abl Abelson murine leukemia oncogene 1; v-abl Abelson murine leukemia viral oncogene 1; v-abl Abelson murine leukemia viral oncogene homolog 1

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基因别名: ABL; ABL1; AI325092; bcr/abl; c-ABL; c-ABL1; E430008G22Rik; JTK7; p150; v-abl

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UniProt ID: (Human) P00519, (Mouse) P00520

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Entrez Gene ID: (Human) 25, (Rat) 311860, (Mouse) 11350

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功能
magnesium ion binding DNA binding actin monomer binding nicotinate-nucleotide adenylyltransferase activity protein kinase activity protein tyrosine kinase activity non-membrane spanning protein tyrosine kinase activity protein kinase C binding receptor binding protein binding ATP binding protein C-terminus binding SH3 domain binding syntaxin binding manganese ion binding actin filament binding mitogen-activated protein kinase binding proline-rich region binding kinase activity protein kinase binding protein domain specific binding delta-catenin binding nucleotide binding transferase activity transferase activity, transferring phosphorus-containing groups metal ion binding
参与通路
B-1 B cell homeostasis B cell proliferation involved in immune response transitional one stage B cell differentiation phagocytosis cellular response to DNA damage stimulus DNA damage induced protein phosphorylation response to oxidative stress epidermal growth factor receptor signaling pathway positive regulation of cytosolic calcium ion concentration learning or memory associative learning cell migration peptidyl-tyrosine phosphorylation cerebellum morphogenesis negative regulation of cell-cell adhesion microspike assembly actin cytoskeleton organization actin filament polymerization negative regulation of BMP signaling pathway regulation of actin cytoskeleton organization positive regulation of osteoblast proliferation substrate adhesion-dependent cell spreading cellular response to oxidative stress response to endoplasmic reticulum stress peptidyl-tyrosine autophosphorylation B cell proliferation response to drug signal transduction in response to DNA damage positive regulation of apoptotic process positive regulation of I-kappaB kinase/NF-kappaB signaling negative regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of neuron apoptotic process innate immune response positive regulation of vasoconstriction negative regulation of mitotic cell cycle positive regulation of mitotic cell cycle alpha-beta T cell differentiation protein autophosphorylation platelet-derived growth factor receptor signaling pathway positive regulation of fibroblast proliferation spleen development thymus development collateral sprouting positive regulation of peptidyl-tyrosine phosphorylation activated T cell proliferation B cell receptor signaling pathway neuromuscular process controlling balance positive regulation of release of sequestered calcium ion into cytosol positive regulation of oxidoreductase activity negative regulation of ubiquitin-protein transferase activity regulation of cell cycle Bergmann glial cell differentiation negative regulation of ERK1 and ERK2 cascade positive regulation of ERK1 and ERK2 cascade cellular response to lipopolysaccharide cellular response to transforming growth factor beta stimulus response to epinephrine negative regulation of protein serine/threonine kinase activity actin filament branching positive regulation of dendrite development positive regulation of interleukin-2 secretion negative regulation of phospholipase C activity positive regulation of neuron death positive regulation of hydrogen peroxide-mediated programmed cell death positive regulation of interferon-gamma secretion regulation of extracellular matrix organization positive regulation of extracellular matrix organization glomerular visceral epithelial cell apoptotic process positive regulation of Wnt signaling pathway, planar cell polarity pathway negative regulation of endothelial cell apoptotic process regulation of cellular senescence negative regulation of cellular senescence regulation of response to DNA damage stimulus positive regulation of protein phosphorylation mismatch repair regulation of transcription, DNA-templated cellular protein modification process autophagy cell cycle arrest mitotic nuclear division intrinsic apoptotic signaling pathway in response to DNA damage regulation of autophagy regulation of endocytosis regulation of cell adhesion regulation of axon extension regulation of microtubule polymerization platelet-derived growth factor receptor-beta signaling pathway Fc-gamma receptor signaling pathway involved in phagocytosis regulation of cell proliferation establishment of protein localization positive regulation of muscle cell differentiation mitochondrial depolarization cellular response to hydrogen peroxide cellular response to dopamine positive regulation of microtubule binding positive regulation of actin filament binding activation of protein kinase C activity regulation of cell motility regulation of actin cytoskeleton reorganization DNA repair protein phosphorylation endocytosis apoptotic process cell adhesion phosphorylation
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