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Phospho-c-Fos (Thr232) Antibody (710688) in WB
Western blot analysis was performed on whole cell extracts (30 µg lysate) of HeLa (lane 1), HeLa treated with EGF (200 µg/mL/10 min), A-431 (lane 3) and A-431 treated with EGF (200 µg/mL/10 min) (lane 4). The blots were probed with Anti-c-Fos (pT232) Recombinant Rabbit Polyclonal Antibody (Product # 710688, 2-3 µg/mL) and detected by chemiluminescence using Goat anti-Rabbit IgG (Heavy Chain) Superclonal Sec... View More
产品信息
710688
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
Expression System
Expi293
分类
Recombinant Superclonal
类型
Antibody
克隆号
3HCLC
抗原
phosphopeptide corresponding to human c-Fos, Thr232 (aa 229-237)
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.2
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2532754
产品详细信息
This antibody is predicted to react with Monkey, Dog, Cat Pig, Bovine, Rat and Mouse.
Recombinant rabbit polyclonal antibodies are unique offerings from Thermo Fisher Scientific. They are comprised of a selection of multiple different recombinant monoclonal antibodies, providing the best of both worlds - the sensitivity of polyclonal antibodies with the specificity of monoclonal antibodies - all delivered with the consistency only found in a recombinant antibody. While functionally the same as a polyclonal antibody - recognizing multiple epitope sites on the target and producing higher detection sensitivity for low abundance targets - a recombinant rabbit polyclonal antibody has a known mixture of light and heavy chains. The exact population can be produced in every lot, circumventing the biological variability typically associated with polyclonal antibody production.
靶标信息
FBJ murine osteosarcoma viral oncogene homolog is commonly known as Cellular protooncogene Fos (c-Fos). It belongs to the fos transcription factor family and is encoded by the C-FOS gene located on chromosome 14. c-Fos heterodimerizes with c-Jun to form the Activator Protein -1 (AP-1) transcription factor which regulates transcription of several genes that play an important role in cellular signal transduction, cell proliferation and differentiation. c-Fos has been shown to be phosphorylated by various stimuli including growth factors and insulin at atleast seven different sites. The best known upstream kinase for phosphorylation at Threonine 232 is ERK MAPK which regulates localization of c-Fos to the nucleus and is thus important for c-Fos induced transcriptional activity.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: activator protein 1; cellular oncogene c-fos; Cellular oncogene fos; FBJ murine osteosarcoma viral (v-fos) oncogene homolog (oncogene FOS); FBJ murine osteosarcoma viral oncogene homolog; Fos proto-oncogene, AP-1 trancription factor subunit; Fos proto-oncogene, AP-1 transcription factor subunit; G0/G1 switch regulatory protein 7; Protein c-Fos; Proto-oncogene c-Fos; Transcription factor AP-1 subunit c-Fos
基因别名: AP-1; C-FOS; FOS; G0S7; p55
UniProt ID: (Human) P01100
Entrez Gene ID: (Human) 2353
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II core promoter sequence-specific DNA binding
transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
protein binding
transcription factor binding
transcription regulatory region DNA binding
protein heterodimerization activity
R-SMAD binding
basic leucine zipper transcription factor
conditioned taste aversion
DNA methylation
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
inflammatory response
transforming growth factor beta receptor signaling pathway
nervous system development
female pregnancy
aging
response to cold
response to light stimulus
response to gravity
response to toxic substance
sleep
cellular response to extracellular stimulus
response to lipopolysaccharide
response to progesterone
cellular response to hormone stimulus
response to cytokine
cellular response to reactive oxygen species
response to immobilization stress
skeletal muscle cell differentiation
response to muscle stretch
Fc-epsilon receptor signaling pathway
response to drug
positive regulation of osteoclast differentiation
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
regulation of sequence-specific DNA binding transcription factor activity
response to corticosterone
response to cAMP
SMAD protein signal transduction
cellular response to calcium ion
positive regulation of pri-miRNA transcription from RNA polymerase II promoter
