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Invitrogen
This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated.
| 应用 | 建议稀释比 | 已发表文章 |
|---|---|---|
免疫印迹 (WB) |
1:1,000 | - |
免疫细胞化学 (ICC/IF) |
1:250 | - |
染色质免疫沉淀 实验 (ChIP) |
1-3 µg x 10^6 cells | - |
| 产品规格 | |
|---|---|
种属反应 |
Human |
宿主/亚型 |
Rabbit / IgG |
分类 |
Polyclonal |
类型 |
Antibody |
抗原 |
The antiserum was produced against a chemically synthesized phosphopeptide derived from the region of human c-Fos that contains threonine 325. The sequence is conserved in human, mouse and rat. |
偶联物 |
Unconjugated |
形式 |
Liquid |
纯化类型 |
Antigen affinity chromatography |
保存液 |
Dulbecco's PBS, pH 7.3, with 1mg/mL BSA |
内含物 |
0.05% sodium azide |
保存条件 |
-20°C |
RRID |
AB_2533622 |
FBJ murine osteosarcoma viral oncogene homolog is commonly known as Cellular protooncogene Fos (c-Fos). It belongs to the fos transcription factor family and is encoded by the C-FOS gene located on chromosome 14. c-Fos heterodimerizes with c-Jun to form the Activator Protein -1 (AP-1) transcription factor which regulates transcription of several genes that play an important role in cellular signal transduction, cell proliferation and differentiation. c-Fos has been shown to be phosphorylated by various stimuli including growth factors and insulin at atleast seven different sites. The best known upstream kinase for phosphorylation at Threonine 232 is ERK MAPK which regulates localization of c-Fos to the nucleus and is thus important for c-Fos induced transcriptional activity.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: activator protein 1; cellular oncogene c-fos; Cellular oncogene fos; FBJ murine osteosarcoma viral (v-fos) oncogene homolog (oncogene FOS); FBJ murine osteosarcoma viral oncogene homolog; Fos proto-oncogene, AP-1 trancription factor subunit; G0/G1 switch regulatory protein 7; Proto-oncogene c-Fos
基因别名: AP-1; C-FOS; FOS; G0S7; p55
UniProt ID: (Human) P01100
Entrez Gene ID: (Human) 2353
