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Invitrogen
Phospho-c-Met (Tyr1349) Recombinant Superclonal Antibody (15HCLC)
高级验证
This Antibody was verified by Cell treatment to ensure that the antibody binds to the antigen stated.
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Phospho-c-Met (Tyr1349) Antibody (710792) in ICC/IF
Immunofluorescence was performed on fixed and permeabilized MKN45 cells which were serum starved for 16 hours and treated with 100 ng of HGF/10 min for detection of cMet (pY1349) using Anti-cMet pY1349 Recombinant Rabbit Polyclonal Antibody (Product # 710792, 1-2 µg/mL) and labeled with Goat anti-Rabbit IgG (Heavy Chain) Superclonal™ Secondary Antibody, Alexa Fluor® 488 conjugate (Product # A27034, 1:2000).... View More
产品信息
710792
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
Expression System
Expi293
分类
Recombinant Superclonal
类型
Antibody
克隆号
15HCLC
抗原
Phosphorylated peptide corresponding to Human MET (aa 1346-1352)
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.2
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2609612
产品详细信息
This antibody is predicted to react with Monkey, Horse, Pig, Bovine, Feline, Goat, Rat and Mouse.
Recombinant rabbit polyclonal antibodies are unique offerings from Thermo Fisher Scientific. They are comprised of a selection of multiple different recombinant monoclonal antibodies, providing the best of both worlds - the sensitivity of polyclonal antibodies with the specificity of monoclonal antibodies - all delivered with the consistency only found in a recombinant antibody. While functionally the same as a polyclonal antibody - recognizing multiple epitope sites on the target and producing higher detection sensitivity for low abundance targets - a recombinant rabbit polyclonal antibody has a known mixture of light and heavy chains. The exact population can be produced in every lot, circumventing the biological variability typically associated with polyclonal antibody production.
靶标信息
MET (cMET) is a receptor-like tyrosine kinase whose dysregulation has been linked to many types of human malignancies. After activation of the ligand, MET interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, and STAT3. There interactions lead to the activation of signaling cascades including RAS-ERK, PI3, kinase-AKT, and PLCgamma-PKC. MET plays a role in embryonic development including gastrulation, development of muscles and neurons, angiogenesis, and kidney formation. It also plays a role in adults including wound healing, organ regeneration, and tissue remodeling. MET has been linked to cancers including gastric, renal, and breast; therefore, making it a target for cancer therapeutics and diagnostic testing.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: cMet; EC 2.7.10.1; Hepatocyte growth factor receptor; HGF receptor; HGF-SF receptor; HGF/SF receptor; oncogene MET; Proto-oncogene c-Met; sc MET; Scatter factor receptor; SF receptor; soluble c met; Tyrosine-protein kinase Met
基因别名: AUTS9; c-Met; DFNB97; HGFR; MET; RCCP2
UniProt ID: (Human) B5A932
Entrez Gene ID: (Human) 4233
endothelial cell morphogenesis
signal transduction
cell surface receptor signaling pathway
cell proliferation
negative regulation of autophagy
peptidyl-tyrosine phosphorylation
positive regulation of transcription from RNA polymerase II promoter
hepatocyte growth factor receptor signaling pathway
branching morphogenesis of an epithelial tube
positive chemotaxis
semaphorin-plexin signaling pathway
negative regulation of hydrogen peroxide-mediated programmed cell death
positive regulation of endothelial cell chemotaxis
