Proteintech

Polycystin 2 Polyclonal Antibody

6 篇参考文献

问题与答案

问题与答案

问题与答案

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抗体检测数据 (7)

Polycystin 2 Antibody in Immunocytochemistry (ICC/IF)

Polycystin 2 Antibody in Immunocytochemistry (ICC/IF)

图: 1 / 7

Polycystin 2 Antibody (19126-1-AP) in ICC/IF

Immunofluorescent analysis of MDCK cells using 19126-1-AP (Polycystin 2 antibody) at dilution of 1:25 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IgG (H+L).

Polycystin 2 Antibody in Immunocytochemistry (ICC/IF)

Polycystin 2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

Polycystin 2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

Polycystin 2 Antibody in Western Blot (WB)

Polycystin 2 Antibody in Western Blot (WB)

Polycystin 2 Antibody in Western Blot (WB)

Polycystin 2 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Polycystin 2 Antibody in Immunocytochemistry (ICC/IF) — Immunofluorescent analysis of MDCK cells using 19126-1-AP (Polycystin 2 antibody) at dilution of 1:25 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IgG (H+L).

Polycystin 2 Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemistry of paraffin-embedded human kidney tissue slide using 19126-1-AP ( Polycystin 2 antibody at dilution of 1:200 (under 40x lens).

Polycystin 2 Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemistry of paraffin-embedded human kidney tissue slide using 19126-1-AP ( Polycystin 2 antibody at dilution of 1:200 (under 10x lens).

Polycystin 2 Antibody in Western Blot (WB) — Mouse kidney tissue were subjected to SDS PAGE followed by western blot with (Product # 19126-1-AP) Polycystin 2 antibody at dilution of 1:8,000 incubated at room temperature for 1.5 hours.

Polycystin 2 Antibody in Western Blot (WB) — Human kidney tissue were subjected to SDS PAGE followed by western blot with 19126-1-AP (Polycystin 2 antibody) at dilution of 1:300 incubated at room temperature for 1.5 hours.

Polycystin 2 Antibody in Western Blot (WB) — HEK-293 cells were subjected to SDS PAGE followed by western blot with 19126-1-AP (Polycystin 2 antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours.

Polycystin 2 Antibody in Immunoprecipitation (IP) — IP result of anti-Polycystin 2 (IP:19126-1-AP, 3ug; Detection:19126-1-AP 1:500) with mouse testis tissue lysate 8000ug.

产品信息

19126-1-AP

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:200-1:1,000

查看3篇已发表文章 3篇已发表文章

免疫组化 (IHC)

-

查看2篇已发表文章 2篇已发表文章

免疫组化（石蜡） (IHC (P))

1:20-1:200

-

免疫细胞化学 (ICC/IF)

1:25

查看1篇已发表文章 1篇已发表文章

免疫沉淀 (IP)

0.5-4.0 µg

-

产品规格

种属反应

Dog, Human, Mouse, Rat

已发表种属

Human, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Peptide

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.21 mg/mL

31.5 µg

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.3, with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20°C

运输条件

Wet ice (domestic); Dry ice (international)

靶标信息

Polycystin-2 (PC2), encoded by the PKD2 gene, is a multi-pass membrane protein that functions as a nonselective calcium-permeable cation channel, primarily localized to the primary cilium and endoplasmic reticulum. It plays a key role in calcium signaling and mechanosensation, often forming a complex with polycystin-1 to regulate cellular responses to fluid flow. Mutations in PKD2 disrupt these processes and lead to autosomal dominant polycystic kidney disease (ADPKD).

仅用于科研。不用于诊断过程。未经明确授权不得转售。

生物信息学

蛋白别名: autosomal dominant polycystic kidney disease type II; Autosomal dominant polycystic kidney disease type II protein; PC2; PKD2; polycystic kidney disease 2 (autosomal dominant); polycystic kidney disease 2 homolog; Polycystic kidney disease 2 protein; Polycystic kidney disease 2 protein homolog; polycystin 2; Polycystin-2; Polycystwin; R48321; Transient receptor potential cation channel subfamily P member 2; unnamed protein product

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基因别名: APKD2; C030034P18Rik; Pc-2; PC2; PKD2; PKD4; RGD1559992; TRPP1; TRPP2

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UniProt ID: (Human) Q13563, (Mouse) O35245

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Entrez Gene ID: (Human) 5311, (Dog) 487852, (Rat) 498328, (Mouse) 18764

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receptor binding voltage-gated ion channel activity voltage-gated calcium channel activity voltage-gated sodium channel activity voltage-gated potassium channel activity cation channel activity calcium channel activity potassium channel activity sodium channel activity calcium ion binding protein binding cytoskeletal protein binding channel activity outward rectifier potassium channel activity voltage-gated cation channel activity identical protein binding protein homodimerization activity actinin binding HLH domain binding ion channel binding metal ion binding calcium-induced calcium release activity ATPase binding phosphoprotein binding muscle alpha-actinin binding transcription regulator inhibitor activity alpha-actinin binding ion channel

branching involved in ureteric bud morphogenesis kidney development liver development embryonic placenta development heart looping detection of nodal flow ion transport potassium ion transport sodium ion transport calcium ion transport cellular calcium ion homeostasis cell surface receptor signaling pathway JAK-STAT cascade determination of left/right symmetry heart development negative regulation of cell proliferation positive regulation of gene expression Wnt signaling pathway calcium-mediated signaling spinal cord development neural tube development ion transmembrane transport cellular response to reactive oxygen species metanephric part of ureteric bud development sodium ion transmembrane transport aorta development regulation of cell proliferation chordate embryonic development cilium organization positive regulation of nitric oxide biosynthetic process positive regulation of transcription from RNA polymerase II promoter embryonic organ development detection of mechanical stimulus release of sequestered calcium ion into cytosol protein tetramerization protein homotetramerization protein heterotetramerization centrosome duplication establishment of localization in cell regulation of cell cycle placenta blood vessel development renal tubule morphogenesis renal artery morphogenesis calcium ion transmembrane transport cellular response to calcium ion cellular response to cAMP cellular response to hydrostatic pressure cellular response to osmotic stress cellular response to fluid shear stress potassium ion transmembrane transport determination of liver left/right asymmetry metanephric mesenchyme development mesonephric tubule development mesonephric duct development metanephric smooth muscle tissue development metanephric cortex development metanephric ascending thin limb development metanephric cortical collecting duct development metanephric distal tubule development metanephric S-shaped body morphogenesis regulation of calcium ion import inorganic cation transmembrane transport positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway negative regulation of G1/S transition of mitotic cell cycle cell cycle arrest positive regulation of cytosolic calcium ion concentration regulation of cAMP metabolic process positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle cytoplasmic sequestering of transcription factor transmembrane transport negative regulation of ryanodine-sensitive calcium-release channel activity positive regulation of cell cycle arrest renal system development transport