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Bethyl Laboratories
Polycystin-2 Polyclonal Antibody
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Polycystin-2 Antibody (A302-470A) in WB
Detection of mouse Polycystin-2 by western blot. Samples: Whole cell lysate (50 µg) from TCMK-1 and NIH 3T3 cells prepared using NETN lysis buffer. Antibody: Affinity purified rabbit anti-Polycystin-2 antibody (Product # A302-470A) (lot A302-470A-3) used for WB at 0.1 µg/mL. Detection: Chemiluminescence with an exposure time of 75 seconds.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
A302-470A
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Region between residue 918 and 968 of Human polycystin-2.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Antigen affinity chromatography
保存液
tris citrate/phosphate, pH 7-8
内含物
0.09% sodium azide
保存条件
4°C
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
The recommended shelf life for this product is 1 year from date of receipt.
靶标信息
Polycystin-2 (PC2), encoded by the PKD2 gene, is a multi-pass membrane protein that functions as a nonselective calcium-permeable cation channel, primarily localized to the primary cilium and endoplasmic reticulum. It plays a key role in calcium signaling and mechanosensation, often forming a complex with polycystin-1 to regulate cellular responses to fluid flow. Mutations in PKD2 disrupt these processes and lead to autosomal dominant polycystic kidney disease (ADPKD).
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: autosomal dominant polycystic kidney disease type II; autosomal dominant polycystic kidney disease type II protein; PKD2; polycystic kidney disease 2 (autosomal dominant); polycystic kidney disease 2 protein homolog; transient receptor potential cation channel subfamily P member 2; unnamed protein product
基因别名: APKD2; C030034P18Rik; Pc-2; PC2; PKD4; TRPP2
UniProt ID: (Human) Q13563, (Mouse) O35245
Entrez Gene ID: (Human) 5311, (Mouse) 18764
receptor binding
voltage-gated ion channel activity
voltage-gated calcium channel activity
voltage-gated sodium channel activity
voltage-gated potassium channel activity
cation channel activity
calcium channel activity
potassium channel activity
sodium channel activity
calcium ion binding
protein binding
cytoskeletal protein binding
channel activity
outward rectifier potassium channel activity
voltage-gated cation channel activity
identical protein binding
protein homodimerization activity
actinin binding
HLH domain binding
ion channel binding
calcium-induced calcium release activity
ATPase binding
phosphoprotein binding
transcription regulator inhibitor activity
muscle alpha-actinin binding
alpha-actinin binding
branching involved in ureteric bud morphogenesis
kidney development
liver development
embryonic placenta development
heart looping
detection of nodal flow
potassium ion transport
sodium ion transport
calcium ion transport
cell surface receptor signaling pathway
JAK-STAT cascade
determination of left/right symmetry
heart development
negative regulation of cell proliferation
positive regulation of gene expression
Wnt signaling pathway
calcium-mediated signaling
spinal cord development
neural tube development
cellular response to reactive oxygen species
metanephric part of ureteric bud development
sodium ion transmembrane transport
aorta development
regulation of cell proliferation
chordate embryonic development
cilium organization
positive regulation of nitric oxide biosynthetic process
positive regulation of transcription from RNA polymerase II promoter
embryonic organ development
detection of mechanical stimulus
release of sequestered calcium ion into cytosol
protein tetramerization
protein homotetramerization
protein heterotetramerization
centrosome duplication
regulation of cell cycle
transmembrane transport
placenta blood vessel development
renal tubule morphogenesis
renal artery morphogenesis
calcium ion transmembrane transport
cellular response to calcium ion
cellular response to cAMP
cellular response to hydrostatic pressure
cellular response to osmotic stress
cellular response to fluid shear stress
potassium ion transmembrane transport
determination of liver left/right asymmetry
metanephric mesenchyme development
mesonephric tubule development
mesonephric duct development
metanephric smooth muscle tissue development
metanephric cortex development
metanephric ascending thin limb development
metanephric cortical collecting duct development
metanephric distal tubule development
metanephric S-shaped body morphogenesis
regulation of calcium ion import
positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway
negative regulation of G1/S transition of mitotic cell cycle
cellular calcium ion homeostasis
positive regulation of cytosolic calcium ion concentration
detection of stimulus
negative regulation of ryanodine-sensitive calcium-release channel activity
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