Bioss

Polycystin 2 Polyclonal Antibody

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}

说明书
实验方案
问题与答案
技术支持
说明书
实验方案
问题与答案
技术支持
说明书
实验方案
问题与答案
技术支持
Polycystin 2 Polyclonal Antibody

产品信息

BS-24450R

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:300-1:5,000
-

酶联免疫吸附实验 (ELISA)

1:500-1:1,000
-
产品规格

种属反应

Human

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

KLH conjugated synthetic peptide derived from human Polycystin 2
查看免疫原

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Protein A

保存液

TBS, pH 7.4, with 1% BSA, 50% glycerol

内含物

0.03% ProClin 300

保存条件

-20°C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

靶标信息

Functions as a calcium permeable cation channel involved in fluid-flow mechanosensation by the primary cilium in renal epithelium. Together with TRPV4, forms mechano- and thermosensitive channels in cilium (PubMed:18695040). PKD1 and PKD2 may function through a common signaling pathway that is necessary for normal tubulogenesis. Acts as a regulator of cilium length, together with PKD1. The dynamic control of cilium length is essential in the regulation of mechanotransductive signaling. The cilium length response creates a negative feedback loop whereby fluid shear-mediated deflection of the primary cilium, which decreases intracellular cAMP, leads to cilium shortening and thus decreases flow-induced signaling. Also involved in left/right axis specification downstream of nodal flow: forms a complex with PKD1L1 in cilia to facilitate flow detection in left/right patterning.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

篇参考文献 (0)

您是否在文献中引用过该产品？请点击下方按钮邮件告知我们。
引用该产品

生物信息学

蛋白别名: Autosomal dominant polycystic kidney disease type II protein; PC2; polycystic kidney disease 2 (autosomal dominant); Polycystic kidney disease 2 protein; Polycystin-2; Polycystwin; R48321; Transient receptor potential cation channel subfamily P member 2; transient receptor potential cation channel, subfamily P, member 2

查看更多 收起

基因别名: APKD2; Pc-2; PC2; PKD2; PKD4; TRPP2

查看更多 收起

UniProt ID: (Human) Q13563

查看更多 收起

Entrez Gene ID: (Human) 5311

查看更多 收起

功能
receptor binding voltage-gated ion channel activity voltage-gated calcium channel activity voltage-gated sodium channel activity potassium channel activity calcium ion binding protein binding cytoskeletal protein binding voltage-gated cation channel activity identical protein binding protein homodimerization activity actinin binding HLH domain binding ion channel binding calcium-induced calcium release activity ATPase binding phosphoprotein binding muscle alpha-actinin binding ion channel
参与通路
branching involved in ureteric bud morphogenesis liver development embryonic placenta development heart looping detection of nodal flow calcium ion transport cell cycle arrest JAK-STAT cascade determination of left/right symmetry heart development negative regulation of cell proliferation spinal cord development neural tube development regulation of cAMP metabolic process positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle cellular response to reactive oxygen species metanephric part of ureteric bud development sodium ion transmembrane transport aorta development regulation of cell proliferation cytoplasmic sequestering of transcription factor positive regulation of nitric oxide biosynthetic process positive regulation of transcription from RNA polymerase II promoter detection of mechanical stimulus release of sequestered calcium ion into cytosol centrosome duplication regulation of postsynaptic membrane potential negative regulation of ryanodine-sensitive calcium-release channel activity placenta blood vessel development renal tubule morphogenesis renal artery morphogenesis calcium ion transmembrane transport positive regulation of cell cycle arrest cellular response to hydrostatic pressure cellular response to osmotic stress cellular response to fluid shear stress potassium ion transmembrane transport determination of liver left/right asymmetry metanephric mesenchyme development mesonephric tubule development mesonephric duct development metanephric smooth muscle tissue development metanephric cortex development metanephric ascending thin limb development metanephric cortical collecting duct development metanephric distal tubule development metanephric S-shaped body morphogenesis regulation of calcium ion import negative regulation of G1/S transition of mitotic cell cycle
guarantee_icon

性能保障

只要您发现Invitrogen抗体在实验中的表现与网站或说明书的所述内容不符，您即可享受免费退换货服务。*

了解更多
help_icon

随时为您服务

获取常见问题的专家解答，或者直接联系我们的技术专家，咨询应用、设备、常规产品使用问题。

联系技术支持