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Invitrogen
Progesterone Receptor Monoclonal Antibody (Alpha PR6)
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Progesterone Receptor Antibody (MA1-411) in ICC/IF
Immunofluorescent analysis of Progesterone Receptor (green) in T47D cells untreated (left) or stimulated with 100nm promegestone, R5020, for 1 hour (right). The cells were fixed with formalin for 15 minutes, permeabilized with 0.1% Triton X-100 in TBS for 10 minutes, and blocked with 3% Blocker BSA (Product # 37525) for 15 minutes at room temperature. Cells were stained with Progesterone Receptor mouse mono... View More
产品信息
MA1-411
应用
建议稀释比
已发表文章
产品规格
种属反应
Bovine,
Chicken,
Guinea pig,
Human,
Mouse,
Sheep,
Rabbit,
Rat
已发表种属
C. elegans,
Camelid,
Chicken,
Human,
Mouse,
Non-human primate,
Rat,
Sheep
宿主/亚型
Mouse
/ IgG2a
分类
Monoclonal
类型
Antibody
克隆号
Alpha PR6
抗原
Progesterone receptor purified from chick oviduct cytosol.
偶联物
形式
Lyophilized
浓度
1 mg/mL
纯化类型
Protein A
保存液
PBS
内含物
0.05% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
MA1-411 reacts with high affinity to the B form of the progesterone receptor from human, mouse, rat, rabbit, bovine, ovine, chicken, and guinea pig tissues. This antibody does not cross-react with estrogen receptor or glucocorticoid receptor.
MA1-411 has been successfully used in Western blot, immunocytochemical, immunohistochemical and immunoprecipitation procedures. By Western blot, this antibody detects a 110 kDa protein representing the B form of the PR in chickens."
The MA1-411 immunogen is progesterone receptor purified from chick oviduct cytosol.
Reconstitute with PBS.
靶标信息
The progesterone receptor (PR) is a member of the steroid family of nuclear receptors. The PR mediates the physiological effects of progesterone, which plays a central role in reproductive events associated with the establishment and maintenance of pregnancy. PR is found as a 94 kDa protein (Form A) or a 120 kDa protein (Form B) due to the use of alternative translation initiation sites. PR-B is the transcriptionally active form and is responsible for activating genes for the maintenance of the endometrium, maintenance of pregnancy, and inhibition of ovulation. PR-A is identical to PR-B except for a 165 amino acid deletion at the N-terminus. This deletion exposes a 140 amino acid inhibitory domain (ID) that acts as a repressor of steroid hormone transcriptional activity. In its inactive state, PgR forms a multiprotein complex which includes heat shock proteins and immunophins. Upon binding of progesterone hormone to its receptor, there is a conformational change that allows dimerization and binding of the receptor to progesterone response elements (PRE) sequences, resulting in activated transcription. A Null mutation in the PGR gene leads to pleiotrophic reproductive abnormalities.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: Nuclear receptor subfamily 3 group C member 3; pot. alt. progesterone receptor; putative; PR; Progesterone receptor; progesterone receptor A; progesterone-receptor; steroid hormone receptor; unnamed protein product
基因别名: 9930019P03Rik; BB114106; ENSMUSG00000074510; NR3C3; PGR; PR; PR-A; PR-B
UniProt ID: (Rabbit) P06186, (Chicken) P07812, (Human) P06401, (Rat) Q63449, (Mouse) Q00175
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcription factor activity, sequence-specific DNA binding
steroid hormone receptor activity
RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
zinc ion binding
enzyme binding
Hsp70 protein binding
chromatin DNA binding
sequence-specific DNA binding
Hsp90 protein binding
steroid hormone binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
DNA binding
steroid binding
protein binding
ATPase binding
receptor binding
hormone binding
lipid binding
metal ion binding
ovulation from ovarian follicle
luteinization
epithelial cell maturation
transcription, DNA-templated
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
positive regulation of cell proliferation
negative regulation of gene expression
positive regulation of smooth muscle cell migration
diterpenoid metabolic process
intracellular receptor signaling pathway
mammary gland development
response to progesterone
response to cocaine
negative regulation of apoptotic process
steroid hormone mediated signaling pathway
response to estrogen
estrous cycle
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
regulation of epithelial cell proliferation
progesterone receptor signaling pathway
female mating behavior
tertiary branching involved in mammary gland duct morphogenesis
cellular response to gonadotropin stimulus
cellular response to follicle-stimulating hormone stimulus
cellular response to luteinizing hormone stimulus
intracellular steroid hormone receptor signaling pathway
transcription initiation from RNA polymerase II promoter
signal transduction
cell-cell signaling
paracrine signaling
lung alveolus development
