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Proteintech
Prohibitin 2 Polyclonal Antibody
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产品信息
12295-1-AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse
已发表种属
Human,
Mouse,
Plant,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Prohibitin 2 Fusion Protein Ag2977 (1-299 aa encoded by BC014766)
偶联物
形式
Liquid
浓度
0.4 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: MAQNLKDLA GRLPAGPRGM GTALKLLLGA GAVAYGVRES VFTVEGGHRA IFFNRIGGVQ QDTILAEGLH FRIPWFQYPI IYDIRARPRK ISSPTGSKDL QMVNISLRVL SRPNAQELPS MYQRLGLDYE ERVLPSIVNE VLKSVVAKFN ASQLITQRAQ VSLLIRRELT ERAKDFSLIL DDVAITELSF SREYTAAVEA KQVAQQEAQR AQFLVEKAKQ EQRQKIVQAE GEAEAAKMLG EALSKNPGYI KLRKIRAAQN ISKTIATSQN RIYLTADNLV LNLQDESFTR GSDSLIKGKK (1-299 aa encoded by BC014766)
靶标信息
PHB2 acts as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases. This protein functions as an estrogen receptor (ER)-selective coregulator that potentiates the inhibitory activities of antiestrogens and represses the activity of estrogens. It competes with NCOA1 for modulation of ER transcriptional activity. It is probably involved in regulating mitochondrial respiration activity and in aging.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: B-cell associated protein; B-cell receptor-associated protein 37; B-cell receptor-associated protein BAP37; D-prohibitin; MGC117268; PHB2; Prohibitin-2; Repressor of estrogen receptor activity
基因别名: AU044498; BAP; Bap37; BCAP37; hBAP; p22; PHB2; PNAS-141; REA
UniProt ID: (Human) Q99623, (Mouse) O35129
Entrez Gene ID: (Human) 11331, (Mouse) 12034
protein import into nucleus, translocation
transcription, DNA-templated
regulation of transcription, DNA-templated
mitochondrion organization
sister chromatid cohesion
positive regulation of exit from mitosis
negative regulation of intracellular estrogen receptor signaling pathway
negative regulation of mammary gland epithelial cell proliferation
negative regulation of apoptotic process
negative regulation of sequence-specific DNA binding transcription factor activity
negative regulation of transcription, DNA-templated
protein stabilization
positive regulation of sequence-specific DNA binding transcription factor activity
mammary gland branching involved in thelarche
mammary gland alveolus development
regulation of branching involved in mammary gland duct morphogenesis
positive regulation of ERK1 and ERK2 cascade
positive regulation of cell cycle G1/S phase transition
regulation of complement activation
