This product is preservative free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%-0.1%).
This antibody has specificity for Human Prolactin Receptor/PRLR.
Prolactin (PRL) is a pituitary hormone involved in the stimulation of milk production, salt and water regulation, growth, development and reproduction. PRL exerts its influence on different cell types through a signal transduction pathway which begins with the binding of the hormone to a transmembrane PRL receptor. Immunoreactive PRL receptor (PRLR), a member of the cytokine receptor family, varies in size (short and long forms) with tissue source and species, from ~40 kDa to 100 kDa. PRLR consists of at least three separate domains: an extracellular region with 5 cysteines which contains the prolactin binding site, a single transmembrane domain and a cytoplasmic region, the length of which appears to influence ligand binding and regulate cellular function.
蛋白别名: hPRL receptor; Prl R; PRL-R; Prolactin receptor; secreted prolactin binding protein
基因别名: HPRL; hPRLrI; MFAB; PRLR
UniProt ID: (Human) P16471
Entrez Gene ID: (Human) 5618
分子生物学功能: transmembrane signal receptor