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NeoBiotechnologies
Pulmonary Surfactant-Associated Protein D (SFTPD) Recombinant Rabbit Monoclonal Antibody (SFTPD/7085R)
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产品信息
6441-RBM8-P1
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
SFTPD/7085R
抗原
Recombinant fragment (around aa241-336) of human SFTPD protein.
偶联物
形式
Liquid
浓度
200 µg/mL
纯化类型
Protein A/G
保存液
PBS with 0.05% BSA
内含物
0.05% sodium azide
保存条件
4°C
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Antibody is stable for 24 months.
Positive Control: Epithelial cells of the lung, skin, small intestine or bladder. Cellular Localization: Secreted.
Specificity Comments: Pulmonary surfactant is primarily responsible for lowering the surface tension at the air-liquid interface in the alveoli, a process that is essential for normal respiration. Pulmonary surfactant is a mixture of phospholipids and proteins, including four distinct surfactant-associated proteins (SPs), SP-A, SP-B, SP-C, SP-D. SP-B and SP-C are predominantly hydrophobic proteins that associate with lipids to promote the absorption of surfactant phospholipids and to reduce the surface tension in the alveoli. SP-A and SP-D are large multimeric proteins belonging to the family of calcium-dependent lectins, designated Collectins, which contribute to the innate immune system. Both SP-A and SP-D have been shown to protect against microbial challenge through binding to the lipid components of the bacterial cell wall and facilitating the rapid removal of microbials.
靶标信息
Surfactant protein D (SP-D) is synthesized and secreted by lung epithelial cells. It belongs to group III of the family of C-type lectins and members of this group has overall structure consisting of multiple globular 'head' regions linked by triple-helical, collagen-like, strands. This group also includes SP-A and the serum proteins mannan-binding protein, conglutinin and collectin-43, all of which have been shown to bind to the C1q receptor found on a wide variety of cells. Both SP-D and SP-A have been shown to enhance oxygen radical production by alveolar macrophages.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Collectin-7; Collectin7; Lung surfactant protein D; PSP-D; PSP-D Surfactant protein D; pulmonary surfactant apoprotein; Pulmonary surfactant associated protein PSP-D; Pulmonary surfactant-associated protein D; SFTP 4; Surfactant associated protein pulmonary 4; surfactant-associated protein, pulmonary 4
基因别名: COLEC7; PSP-D; PSPD; SFTP4; SFTPD; SP-D
UniProt ID: (Human) P35247
Entrez Gene ID: (Human) 6441
regulation of cytokine production
receptor-mediated endocytosis
respiratory gaseous exchange
negative regulation of T cell proliferation
defense response to bacterium
surfactant homeostasis
cellular protein metabolic process
negative regulation of interleukin-2 biosynthetic process
innate immune response
macrophage chemotaxis
lung alveolus development
positive regulation of phagocytosis
regulation of immune response
reactive oxygen species metabolic process
