Proteintech

RAB11A/B Polyclonal Antibody

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RAB11A/B Polyclonal Antibody

产品信息

15903-1-AP

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:500-1:2,000
查看13篇已发表文章 13篇已发表文章

免疫组化 (IHC)

-
查看5篇已发表文章 5篇已发表文章

免疫组化（石蜡） (IHC (P))

1:50-1:500
-

免疫细胞化学 (ICC/IF)

1:50-1:500
查看11篇已发表文章 11篇已发表文章

免疫沉淀 (IP)

0.5-4.0 µg
查看2篇已发表文章 2篇已发表文章

其他PubMed (Misc)

-
查看1篇已发表文章 1篇已发表文章

不适用 (N/A)

-
查看1篇已发表文章 1篇已发表文章
产品规格

种属反应

Human, Mouse

已发表种属

Dog, Human

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

RAB11A/B Fusion Protein Ag8742 (1-216 aa encoded by BC013348)
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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.27 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.3, with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20°C

运输条件

Wet ice (domestic); Dry ice (international)

产品详细信息

This antibody can recognize both RAB11A (24 kDa) and RAB11B(24 kDa).

Immunogen sequence: MGTRDDEYD YLFKVVLIGD SGVGKSNLLS RFTRNEFNLE SKSTIGVEFA TRSIQVDGKT IKAQIWDTAG QERYRAITSA YYRGAVGALL VYDIAKHLTY ENVERWLKEL RDHADSNIVI MLVGNKSDLR HLRAVPTDEA RAFAEKNGLS FIETSALDST NVEAAFQTIL TEIYRIVSQK QMSDRRENDM SPSNNVVPIH VPPTTENKPK VQCCQNI (1-216 aa encoded by BC013348)

靶标信息

Rab11A is a member of the YPT-1 subfamily of Ras-related GTP-binding proteins. Rab11A mRNA has been detected in a variety of tissues including brain, testis, spleen, heart, and gastrointestinal mucosa. In the gastric fundus the Rab11A protein is expressed in parietal cell tubulovesicles membranes. Expression of the Rab11A protein appears to occur in discrete epithelial cell populations where it localizes to apical vesicular populations. Recent studies have shown Rab11A is essential for resecretion of alpha-synuclein out of neuronal cells via endosome recycling and is required for exocytosis of discoidal/fusiform vesicles of bladder umbrella cells. Rab11A is also implicated in biogenesis of Birbeck granules and endosomal activation of the PI3K/AKT signaling pathway via G beta gamma trafficking.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

生物信息学

蛋白别名: GTP-binding protein YPT3; RAB 11A, member oncogene family; Rab-11; RAB11B, member of RAS oncogene family; RAS oncogene family protein; Ras-related protein Rab-11A; Ras-related protein Rab-11B; YL8

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基因别名: A730055L17Rik; H-YPT3; RAB11; RAB11A; RAB11B; YL8; YPT3

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UniProt ID: (Human) P62491, (Human) Q15907, (Mouse) P62492, (Mouse) P46638

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Entrez Gene ID: (Human) 8766, (Human) 9230, (Mouse) 53869, (Mouse) 19326

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功能
GTPase activity protein binding GTP binding microtubule binding syntaxin binding myosin V binding GDP binding cadherin binding involved in cell-cell adhesion nucleotide binding
参与通路
receptor recycling small GTPase mediated signal transduction melanosome transport transferrin transport insulin secretion involved in cellular response to glucose stimulus regulation of anion transport constitutive secretory pathway regulated exocytosis cellular response to acidic pH establishment of protein localization to membrane cell-cell adhesion retrograde transport, endosome to plasma membrane regulation of protein localization to cell surface regulation of endocytic recycling cytokinesis renal water homeostasis mitotic metaphase plate congression positive regulation of epithelial cell migration regulation of multivesicular body size positive regulation of G2/M transition of mitotic cell cycle protein transport vesicle-mediated transport astral microtubule organization neuron projection development multivesicular body assembly positive regulation of axon extension regulation of long-term neuronal synaptic plasticity plasma membrane to endosome transport regulation of protein transport establishment of vesicle localization regulation of vesicle-mediated transport establishment of protein localization to organelle protein localization to plasma membrane mitotic spindle assembly exosomal secretion transport intracellular protein transport exocytosis cell cycle metabolic process Rab protein signal transduction endocytosis
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