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产品信息
PA5-50109
| 应用 | 建议稀释比 | 已发表文章 |
|---|---|---|
免疫印迹 (WB) |
1:500-1:3,000 | - |
| 产品规格 | |
|---|---|
种属反应 |
Human, Mouse |
宿主/亚型 |
Rabbit / IgG |
分类 |
Polyclonal |
类型 |
Antibody |
抗原 |
Synthesized peptide derived from internal of human RAB7L1. |
偶联物 |
Unconjugated |
形式 |
Liquid |
浓度 |
1 mg/mL |
纯化类型 |
Antigen affinity chromatography |
保存液 |
PBS, pH 7.4, with 50% glycerol |
内含物 |
0.02% sodium azide |
保存条件 |
-20°C |
RRID |
AB_2635562 |
产品详细信息
The antibody detects endogenous levels of total RAB29 protein.
靶标信息
Rab GTPase key regulator in vesicle trafficking. Essential for maintaining the integrity of the endosome-trans-Golgi network structure. Together with LRRK2, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose 6 phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner. Regulates neuronal process morphology in the intact central nervous system (CNS). May play a role in the formation of typhoid toxin transport intermediates during Salmonella enterica serovar Typhi (S.Typhi) epithelial cell infection. {ECO:0000269; PubMed:22042847, ECO:0000269; PubMed:24788816}.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Rab-7-like protein 1; RAB7, member RAS oncogene family-like 1; Ras-related protein Rab-29; Ras-related protein Rab-7L1
基因别名: RAB29; RAB7L; RAB7L1
UniProt ID: (Human) O14966
Entrez Gene ID: (Human) 8934, (Mouse) 226422
transport
intracellular protein transport
Golgi organization
small GTPase mediated signal transduction
protein transport
cell differentiation
melanosome organization
Rab protein signal transduction
retrograde transport, plasma membrane to Golgi
positive regulation of intracellular protein transport
ER to Golgi vesicle-mediated transport
Golgi to endosome transport
response to bacterium
negative regulation of neuron projection development
symbiont intracellular protein transport in host
retrograde transport, endosome to Golgi
protein localization to membrane
regulation of neuron death
