Invitrogen

RAB8A Polyclonal Antibody

产品信息

PA5-50483

应用	建议稀释比	已发表文章
免疫印迹 (WB)	1:500-1:2,000	-

产品规格
种属反应	Human
宿主/亚型	Rabbit / IgG
分类	Polyclonal
类型	Antibody
抗原	Synthetic peptide corresponding to a region derived from internal residues of human Ras-related protein Rab-8A
偶联物	Unconjugated
形式	Liquid
浓度	0.7 mg/mL
纯化类型	Antigen affinity chromatography
保存液	PBS, pH 7.4, with 40% glycerol
内含物	0.05% sodium azide
保存条件	-20°C
RRID	AB_2635936

产品详细信息

The antibody detects endogenous levels of total RAB8A protein.

靶标信息

The protein encoded by this gene is a member of the RAS superfamily which are small GTP/GDP-binding proteins with an average size of 200 amino acids. The RAS-related proteins of the RAB/YPT family may play a role in the transport of proteins from the endoplasmic reticulum to the Golgi and the plasma membrane. This protein shares 97%, 96%, and 51% similarity with the dog RAB8, mouse MEL, and mouse YPT1 proteins, respectively and contains the 4 GTP/GDP-binding sites that are present in all the RAS proteins. The putative effector-binding site of this protein is similar to that of the RAB/YPT proteins. However, this protein contains a C-terminal CAAX motif that is characteristic of many RAS superfamily members but which is not found in YPT1 and the majority of RAB proteins. Although this gene was isolated as a transforming gene from a melanoma cell line, no linkage between MEL and malignant melanoma has been demonstrable. This oncogene is located 800 kb distal to MY09B on chromosome 19p13.1.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: mel transforming oncogene (derived from cell line NK14); mel transforming oncogene (derived from cell line NK14)- RAB8 homolog; mel transforming oncogene (RAB8 homolog); Oncogene c-mel; ras-associated protein RAB8; Ras-related protein Rab-8A

基因别名: MEL; RAB8; RAB8A

UniProt ID: (Human) P61006

Entrez Gene ID: (Human) 4218

功能

G2/M transition of mitotic cell cycle vesicle docking involved in exocytosis small GTPase mediated signal transduction axonogenesis protein secretion cellular response to insulin stimulus cilium assembly regulation of long-term neuronal synaptic plasticity Golgi vesicle fusion to target membrane regulation of protein transport membrane organization protein localization to plasma membrane

参与通路

GTPase activity protein binding GTP binding Rab GTPase binding GDP binding protein kinase binding myosin V binding

RAB8A Polyclonal Antibody

产品信息

PA5-50483

免疫印迹 (WB)

种属反应

宿主/亚型

分类

类型

抗原

偶联物

形式

浓度

纯化类型

保存液

内含物

保存条件

RRID

产品详细信息

靶标信息

篇参考文献 (0)

生物信息学

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