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RACK1 Antibody (711276) in WB
Western blot analysis was performed on Whole cell extracts (30 µg lysate) of NIH/3T3 (Lane 1), C2C12 (Lane 2), HeLa (Lane 3), MCF7 (Lane 4) and U-2 OS (Lane 5). The blots were probed with Anti-RacK1/GNB2L1 Recombinant Rabbit Polyclonal Antibody (Product # 711276, 1-2 µg/mL) and detected by chemiluminescence using Goat anti-Rabbit IgG (Heavy Chain) Superclonal Secondary Antibody, HRP conjugate (Product # A27036, 0.4 µg/mL, 1:2500 dilution). Two isoforms of 35 and 32 kDa band corresponding to RacK1/GNB2L1 was observed across the cell lines t... View More
产品信息
711276
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
Expression System
Expi293
分类
Recombinant Superclonal
类型
Antibody
克隆号
23HCLC
抗原
Peptides corresponding to human RACK1 (aa268-285, aa139-152)
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2663064
产品详细信息
This antibody is predicted to react with Monkey, Cat, Sheep
Recombinant rabbit polyclonal antibodies are unique offerings from Thermo Fisher Scientific. They are comprised of a selection of multiple different recombinant monoclonal antibodies, providing the best of both worlds - the sensitivity of polyclonal antibodies with the specificity of monoclonal antibodies - all delivered with the consistency only found in a recombinant antibody. While functionally the same as a polyclonal antibody - recognizing multiple epitope sites on the target and producing higher detection sensitivity for low abundance targets - a recombinant rabbit polyclonal antibody has a known mixture of light and heavy chains. The exact population can be produced in every lot, circumventing the biological variability typically associated with polyclonal antibody production.
靶标信息
RACK1 (receptor for activated C kinase 1) was identified through its binding to various PKC isoforms. Its main function is to recruit PKC and various other proteins to specific locations to form multiprotein complexes, mediating various signal pathways. RACK1 is required for VANGL2 membrane localization and for PTK2/FAK1 phosphorylation and dephosphorylation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 12-3; activated protein kinase C receptor; Cell proliferation-inducing gene 21 protein; guanine nucleotide binding protein (G protein), beta polypeptide 2 like 1 sequence 1; guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1; guanine nucleotide binding protein beta polypeptide 2-like 1; guanine nucleotide binding protein related; guanine nucleotide binding protein, beta 2, related sequence 1; guanine nucleotide binding protein, beta-2, related sequence 1; Guanine nucleotide-binding protein subunit beta-2-like 1; Guanine nucleotide-binding protein subunit beta-like protein 12.3; HLC-7; Human lung cancer oncogene 7 protein; lung cancer oncogene 7; OTTHUMP00000223870; OTTHUMP00000223891; OTTHUMP00000223893; OTTHUMP00000223900; OTTHUMP00000223901; OTTHUMP00000223902; OTTHUMP00000223930; OTTHUMP00000223931; p205; proliferation-inducing gene 21; protein homologous to chicken B complex protein, guanine nucleotide binding; rack-1; Receptor for activated C kinase; Receptor of activated protein C kinase 1; Receptor of activated protein kinase C 1; Small ribosomal subunit protein RACK1
基因别名: AL033335; GB-like; Gnb2-rs1; GNB2L1; H12.3; HLC-7; HLC7; p205; PIG21; RACK1
UniProt ID: (Mouse) P68040, (Human) P63244
Entrez Gene ID: (Mouse) 14694, (Human) 10399
receptor activity
protein kinase C binding
protein binding
ion channel inhibitor activity
cysteine-type endopeptidase activator activity involved in apoptotic process
enzyme binding
protein phosphatase binding
protein tyrosine kinase inhibitor activity
receptor tyrosine kinase binding
signaling adaptor activity
SH2 domain binding
protein homodimerization activity
poly(A) RNA binding
receptor binding
protein complex scaffold
cadherin binding involved in cell-cell adhesion
osteoblast differentiation
positive regulation of protein phosphorylation
regulation of translation
apoptotic process
activation of cysteine-type endopeptidase activity involved in apoptotic process
cell cycle
multicellular organism development
gastrulation
protein localization
negative regulation of gene expression
negative regulation of translation
negative regulation of cell growth
positive regulation of cell migration
positive regulation of cAMP catabolic process
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
positive regulation of protein homooligomerization
negative regulation of peptidyl-serine phosphorylation
intracellular signal transduction
regulation of growth
positive regulation of apoptotic process
positive regulation of GTPase activity
rhythmic process
negative regulation of phagocytosis
positive regulation of cyclic-nucleotide phosphodiesterase activity
regulation of cell cycle
negative regulation of protein kinase B signaling
positive regulation of mitochondrial depolarization
negative regulation of protein tyrosine kinase activity
cellular response to glucose stimulus
regulation of establishment of protein localization to plasma membrane
negative regulation of hydrogen peroxide-induced neuron death
positive regulation of intrinsic apoptotic signaling pathway
regulation of tumor necrosis factor-mediated signaling pathway
viral process
negative regulation of Wnt signaling pathway
regulation of protein localization
positive regulation of Golgi to plasma membrane protein transport
regulation of cell division
cellular response to growth factor stimulus
cell-cell adhesion
negative regulation of endoplasmic reticulum unfolded protein response
regulation of establishment of cell polarity
positive regulation of ceramide biosynthetic process
positive regulation of gastrulation
