Invitrogen

RAD23B Polyclonal Antibody

产品信息

PA5-50168

应用	建议稀释比	已发表文章
免疫印迹 (WB)	1:500-1:3,000	-

产品规格
种属反应	Human, Mouse, Rat
宿主/亚型	Rabbit / IgG
分类	Polyclonal
类型	Antibody
抗原	Synthesized peptide derived from N-terminal of human RAD23B. 查看免疫原
偶联物	Unconjugated
形式	Liquid
浓度	1 mg/mL
纯化类型	Antigen affinity chromatography
保存液	PBS, pH 7.4, with 50% glycerol
内含物	0.02% sodium azide
保存条件	-20°C
RRID	AB_2635621

产品详细信息

The antibody detects endogenous levels of total RAD23B protein.

靶标信息

The protein encoded by this gene is one of two human homologs of Saccharomyces cerevisiae Rad23, a protein involved in the nucleotide excision repair (NER). This protein was found to be a component of the protein complex that specifically complements the NER defect of xeroderma pigmentosum group C (XP-c) cell extracts in vitro. This protein was also shown to interact with, and elevate the nucleotide excision activity of 3-methyladenine-DNA glycosylase (MPG), which suggested a role in DNA damage recognition in base excision repair. This protein contains an N-terminal ubiquitin-like domain, which was reported to interact with 26S proteasome, and thus this protein may be involved in the ubiquitin mediated proteolytic pathway in cells.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: HR23B; p58; RAD23, yeast homolog of, B; RAD23b homolog; UV excision repair protein RAD23 homolog B; XP-C repair complementing complex 58 kDa; XP-C repair complementing protein; XP-C repair-complementing complex 58 kDa protein

基因别名: 0610007D13Rik; AV001138; HHR23B; HR23B; Mhr23b; P58; RAD23B

UniProt ID: (Human) P54727, (Mouse) P54728, (Rat) Q4KMA2

Entrez Gene ID: (Human) 5887, (Mouse) 19359, (Rat) 298012

分子生物学功能: damaged DNA-binding protein