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Proteintech
RAF1 Polyclonal Antibody
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产品信息
12388-1-AP
产品规格
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
RAF1 Fusion Protein Ag3060 (349-648 aa encoded by BC018119)
偶联物
形式
Liquid
浓度
0.2 mg/mL
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: VMLSTRIGS GSFGTVYKGK WHGDVAVKIL KVVDPTPEQF QAFRNEVAVL RKTRHVNILL FMGYMTKDNL AIVTQWCEGS SLYKHLHVQE TKFQMFQLID IARQTAQGMD YLHAKNIIHR DMKSNNIFLH EGLTVKIGDF GLATVKSRWS GSQQVEQPTG SVLWMAPEVI RMQDNNPFSF QSDVYSYGIV LYELMTGELP YSHINNRDQI IFMVGRGYAS PDLSKLYKNC PKAMKRLVAD CVKKVKEERP LFPQILSSIE LLQHSLPKIN RSASEPSLHR AAHTEDINAC TLTTSPRLPV F (349-648 aa encoded by BC018119)
靶标信息
Raf-1 (c-Raf) is a MAP kinase kinase kinase (MAP3K) which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated Raf-1 can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2 which in turn phosphorylate to activate the serine/threonine specific protein kinases ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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