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Invitrogen
RALA Polyclonal Antibody
高级验证
This Antibody was verified by Knockdown to ensure that the antibody binds to the antigen stated.
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RALA Antibody (PA5-22333) in WB
Western blot was performed using Anti-RALA Rabbit Polyclonal Antibody (Product # PA5-22333) and a 26 kDa band corresponding to RALA was observed across cell line and tissues tested along with an uncharacterized band (*) at ~110 kDa. Membrane enriched cell extracts (30 µg lysate) of NTERA-2 (Lane 1), tissue extracts of Mouse brain (Lane 2), and Rat brain (Lane 3) were electrophoresed using Novex® NuPAGE® 4-12 % Bis-Tris gel (Product # NP0321BOX). Resolved proteins were then transferred onto a nitrocellulose membrane (Product # IB23001) by i... View More
产品信息
PA5-22333
产品规格
种属反应
Amphibian,
Human,
Mouse,
Rodent,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fragment corresponding to a region within amino acids 1 and 206 of RALA (Uniprot ID#P11233)
偶联物
形式
Liquid
浓度
0.55 mg/mL
纯化类型
Antigen affinity chromatography
保存液
0.1M tris glycine, pH 7, with 20% glycerol
内含物
0.01% thimerosal
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_11156400
产品详细信息
Recommended positive controls: HepG2, mouse brain, rat lung.
Predicted reactivity: Mouse (99%), Rat (99%), Drosophila (86%), Xenopus laevis (97%), Rhesus Monkey (100%), Bovine (98%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking. Accomplishes its multiple functions by interacting with distinct downstream effectors. Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles. Plays a role in the early stages of cytokinesis and is required to tether the exocyst to the cytokinetic furrow. The RALA-exocyst complex regulates integrin-dependent membrane raft exocytosis and growth signaling. Key regulator of LPAR1 signaling and competes with GRK2 for binding to LPAR1 thus affecting the signaling properties of the receptor. Required for anchorage-independent proliferation of transformed cells.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: -ral simian leukemia viral oncogene homolog A (ras related); MGC48949; ral-A protein; Ras family small GTP binding protein RALA; ras related GTP binding protein A; RAS-like protein A; RAS-like, family 1; Ras-related protein Ral-A; v-ral simian leukemia viral oncogene homolog A (ras related)
基因别名: 3010001O15Rik; AW322615; RAL; Ral-a; RALA; Rasl1
UniProt ID: (Human) P11233, (Mouse) P63321, (Rat) P63322
Entrez Gene ID: (Human) 5898, (Mouse) 56044, (Rat) 81757
cytokinesis
neural tube closure
exocytosis
chemotaxis
signal transduction
Ras protein signal transduction
viral process
regulation of exocytosis
actin cytoskeleton reorganization
positive regulation of filopodium assembly
membrane raft localization
membrane organization
cell cycle
small GTPase mediated signal transduction
cell division
metabolic process
