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| 应用 | 建议稀释比 | 已发表文章 |
|---|---|---|
免疫印迹 (WB) |
1:500-1:2,000 | - |
免疫组化 (IHC) |
1:200-1:1,000 | - |
免疫组化（石蜡） (IHC (P)) |
1:200-1:1,000 | - |
免疫细胞化学 (ICC/IF) |
1:200-1:1,000 | - |
流式细胞分析 (Flow) |
1:200-1:400 | - |
酶联免疫吸附实验 (ELISA) |
1:10,000 | - |
| 产品规格 | |
|---|---|
种属反应 |
Human, Mouse, Non-human primate |
宿主/亚型 |
Mouse / IgG1 |
分类 |
Monoclonal |
类型 |
Antibody |
克隆号 |
4G8C7 |
抗原 |
Purified recombinant fragment of human RALA (AA: 71-203) expressed in E. coli. |
偶联物 |
Unconjugated |
形式 |
Liquid |
浓度 |
1 mg/mL |
纯化类型 |
Protein G |
保存液 |
PBS |
内含物 |
0.05% sodium azide |
保存条件 |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
RRID |
AB_2787514 |
Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking. Accomplishes its multiple functions by interacting with distinct downstream effectors. Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles. Plays a role in the early stages of cytokinesis and is required to tether the exocyst to the cytokinetic furrow. The RALA-exocyst complex regulates integrin-dependent membrane raft exocytosis and growth signaling. Key regulator of LPAR1 signaling and competes with GRK2 for binding to LPAR1 thus affecting the signaling properties of the receptor. Required for anchorage-independent proliferation of transformed cells.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: MGC48949; ral-A protein; Ras family small GTP binding protein RALA; ras related GTP binding protein A; RAS-like protein A; RAS-like, family 1; Ras-related protein Ral-A; v-ral simian leukemia viral oncogene homolog A (ras related)
基因别名: 3010001O15Rik; AW322615; RAL; Ral-a; RALA; Rasl1
UniProt ID: (Human) P11233, (Mouse) P63321
Entrez Gene ID: (Human) 5898, (Mouse) 56044
分子生物学功能:
small GTPase
