FIGURE: 1 / 5
Western blot analysis of MA1-013 detects an ~21kDa protein.
The product of this gene belongs to the family of RAS-related proteins. These proteins share approximately 50% amino acid identity with the classical RAS proteins and have numerous structural features in common. The most striking difference between RAP proteins and RAS proteins resides in their 61st amino acid: glutamine in RAS is replaced by threonine in RAP proteins. The product of this gene counteracts the mitogenic function of RAS because it can interact with RAS GAPs and RAF in a competitive manner. Two transcript variants encoding the same protein have been identified for this gene.
Protein Aliases: C21KG; G-22K; GTP-binding protein smg p21A; GTP-binding protein SMG-P21A; Ras-related protein Krev-1; Ras-related protein Rap-1A
Gene Aliases: AI848598; C21KG; G-22K; KREV-1; KREV1; RAP1; RAP1A; SMGP21
Molecular Function: small GTPase