Sequence homology: Cow: 93%; Dog: 93%; Guinea Pig: 86%; Horse: 93%; Human: 100%; Mouse: 93%; Rabbit: 86%; Rat: 93%; Sheep: 93%; Zebrafish: 79%
RAP2A is a small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form. In its active form interacts with and regulates several effectors including MAP4K4, MINK1 and TNIK. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it is part of several signaling cascades and may regulate cytoskeletal rearrangements, cell migration, cell adhesion and cell spreading.
蛋白别名: RAP2, member of RAS oncogene family (K-rev); Ras-related protein Rap-2a; RbBP-30; RP11-128N14.2
基因别名: K-REV; KREV; RAP2; RAP2A; RbBP-30
UniProt ID: (Human) P10114
Entrez Gene ID: (Human) 5911
分子生物学功能: small GTPase