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Proteintech
RAP2A Monoclonal Antibody (1F6F3)
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RAP2A Antibody (68368-1-IG) in WB
Various lysates were subjected to SDS PAGE followed by western blot with 68368-1-Ig (RAP2A antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. The membrane was stripped and reblotted with HRP-conjugated GAPDH Monoclonal antibody (HRP-60004) as loading control.
产品信息
68368-1-IG
产品规格
种属反应
Human,
Mouse,
Pig,
Rabbit,
Rat
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
1F6F3
抗原
Recombinant protein
偶联物
形式
Liquid
纯化类型
Protein G
保存液
PBS with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
产品详细信息
Immunogen sequence: MREYKVVVLG SGGVGKSALT VQFVTGTFIE KYDPTIEDFY RKEIEVDSSP SVLEILDTAG TEQFASMRDL YIKNGQGFIL VYSLVNQQSF QDIKPMRDQI IRVKRYEKVP VILVGNKVDL ESEREVSSSE GRALAEEWGC PFMETSAKSK TMVDELFAEI VRQMNYAAQP DKDDPCCSAC NIQ
靶标信息
RAP2A is a small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form. In its active form interacts with and regulates several effectors including MAP4K4, MINK1 and TNIK. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it is part of several signaling cascades and may regulate cytoskeletal rearrangements, cell migration, cell adhesion and cell spreading.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: RAP2, member of RAS oncogene family (K-rev); rap2A-like protein; RAS related protein 2a inverted question mark; Ras-related protein Rap-2a; RbBP-30; RP11-128N14.2
基因别名: 5830461H18Rik; K-REV; KREV; RAP2; RAP2A; RbBP-30
UniProt ID: (Human) P10114, (Mouse) Q80ZJ1
Entrez Gene ID: (Pig) 100155367, (Human) 5911, (Rat) 114560, (Mouse) 76108
positive regulation of protein phosphorylation
microvillus assembly
negative regulation of cell migration
actin cytoskeleton reorganization
positive regulation of protein autophosphorylation
Rap protein signal transduction
cellular protein localization
cellular response to drug
establishment of protein localization
establishment of epithelial cell apical/basal polarity
regulation of JNK cascade
regulation of dendrite morphogenesis
protein localization to plasma membrane
metabolic process
signal transduction
small GTPase mediated signal transduction
