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RAPGEF3 Antibody (PA5-96094) in WB
Western blot analysis of RAPGEF3 in extracts of various cell lines. Samples were incubated with RAPGEF3 Polyclonal antibody (Product # PA5-96094) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST.
产品信息
PA5-96094
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human Epac1/Epac1/RAPGEF3 (NP_0010920021)
偶联物
形式
Liquid
浓度
0.35 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2807896
产品详细信息
Immunogen sequence: MVLRRMHRPR SCSYQLLLEH QRPSCIQGLR WTPLTNSEES LDFSESLEQA STERVLRAGR QLHRHLLATC PNLIRDRKYH LRLYRQCCSG RELVDGILAL GLGVHSRSQV VGICQVLLDE GALCHVKHDW AFQDRDAQFY RFPGPEPEPV GTHEMEEELA EAVALLSQRG PDALLTVALR KPPGQRTDEE LDLIFEELLH; Positive Samples: Mouse heart, Mouse thymus; Cellular Location: Endomembrane system
靶标信息
Gene ontology (GO) annotation includes small GTPase mediated signal transduction. Target protein binds cAMP and activates the Ras superfamily guanine nucleotide binding protein (Rap1A)in a PKA-independent manner.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 9330170P05Rik; cAMP-GEFI; cAMP-regulated guanine nucleotide exchange factor I; EPAC 1; Exchange factor directly activated by cAMP 1; Exchange protein directly activated by cAMP 1; MGC21410; Rap guanine nucleotide exchange factor (GEF) 3; Rap guanine nucleotide exchange factor 3; Rap1 guanine-nucleotide-exchange factor directly activated by cAMP
基因别名: 2310016P22Rik; 9330170P05Rik; bcm910; CAMP-GEFI; CGEF1; EPAC; EPAC1; HSU79275; RAPGEF3
UniProt ID: (Human) O95398, (Mouse) Q8VCC8
Entrez Gene ID: (Human) 10411, (Mouse) 223864
angiogenesis
signal transduction
brain development
cell proliferation
negative regulation of cardiac muscle cell apoptotic process
positive regulation of smooth muscle cell migration
cAMP-mediated signaling
spinal cord development
positive regulation of cAMP catabolic process
Rap protein signal transduction
negative regulation of collagen biosynthetic process
positive regulation of peptidyl-serine phosphorylation
negative regulation of syncytium formation by plasma membrane fusion
response to nicotine
cellular response to drug
positive regulation of GTPase activity
positive regulation of angiogenesis
positive regulation of cell size
positive regulation of transcription from RNA polymerase II promoter
positive regulation of protein export from nucleus
regulation of insulin secretion
positive regulation of stress fiber assembly
positive regulation of syncytium formation by plasma membrane fusion
artery development
establishment of endothelial barrier
cellular response to cAMP
cellular response to transforming growth factor beta stimulus
liver regeneration
positive regulation of protein acetylation
positive regulation of GTP binding
positive regulation of calcium ion transmembrane transport
positive regulation of hydrogen:potassium-exchanging ATPase activity
cellular response to L-dopa
dorsal root ganglion development
regulation of actin cytoskeleton reorganization
positive regulation of actin cytoskeleton reorganization
regulation of histone H3-K9 acetylation
regulation of protein phosphorylation
positive regulation of protein phosphorylation
small GTPase mediated signal transduction
positive regulation of ATPase activity
intracellular signal transduction
positive regulation of binding
positive regulation of calcium ion transport
negative regulation of cell death
