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产品信息
PA5-50106
| 应用 | 建议稀释比 | 已发表文章 |
|---|---|---|
免疫印迹 (WB) |
1:500-1:3,000 | - |
| 产品规格 | |
|---|---|
种属反应 |
Human, Mouse |
宿主/亚型 |
Rabbit / IgG |
分类 |
Polyclonal |
类型 |
Antibody |
抗原 |
Synthesized peptide derived from internal of human RAPGEF5. |
偶联物 |
Unconjugated |
形式 |
Liquid |
浓度 |
1 mg/mL |
纯化类型 |
Antigen affinity chromatography |
保存液 |
PBS, pH 7.4, with 50% glycerol |
内含物 |
0.02% sodium azide |
保存条件 |
-20°C |
RRID |
AB_2635559 |
产品详细信息
The antibody detects endogenous levels of total RAPGEF5 protein.
靶标信息
Members of the RAS subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as Repac, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation. Repac, also known as Rap guanine nucleotide exchange factor 5 (RAPGEF5), is a 580 amino acid protein that is expressed in brain and testis, with weaker expression in heart, placenta, lung, pancreas and small intestine. Existing as two alternatively spliced isoforms, the Repac gene is conserved in cow, mouse and rat. The gene that encodes Repac maps to human chromosome 7p15.3, with high expression of this region linking to positive response to erlotinib therapy for those with non-small-cell lung cancer.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Guanine nucleotide exchange factor for Rap1; M-Ras-regulated GEF; M-Ras-regulated Rap GEF; MR-GEF; Mras regulated guanine nucleotide exchange factor; Rap guanine nucleotide exchange factor (GEF) 5; Rap guanine nucleotide exchange factor 5; Related to Epac; Repac; tcag7.1034
基因别名: 4932413M22; C86120; D030051B22Rik; GFR; KIAA0277; mKIAA0277; mmr-gef; MR-GEF; MRGEF; RAPGEF5; REPAC
UniProt ID: (Human) Q92565, (Mouse) Q8C0Q9
Entrez Gene ID: (Human) 9771, (Mouse) 217944
分子生物学功能:
guanyl-nucleotide exchange factor
