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RARB Monoclonal Antibody (R beta 28)

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RARB Monoclonal Antibody (R beta 28)

产品信息

MA1-811

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:500-1:5,000
查看3篇已发表文章 3篇已发表文章

免疫细胞化学 (ICC/IF)

1:250
-

酶联免疫吸附实验 (ELISA)

-
查看1篇已发表文章 1篇已发表文章
产品规格

种属反应

Human, Mouse, Rat

已发表种属

Fish, Mouse, Non-human primate, Yeast

宿主/亚型

Mouse / IgG2a

分类

Monoclonal

类型

Antibody

克隆号

R beta 28

抗原

Synthetic peptide corresponding to the C-terminal sequence of the mouse RAR beta.
查看免疫原

偶联物

Unconjugated Unconjugated Unconjugated

形式

Lyophilized

浓度

Conc. Not Determined

规格

50 µg

保存液

ascites

内含物

0.05% sodium azide

保存条件

-20°C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2177762

产品详细信息

MA1-811 detects retinoic acid receptor (RAR) beta from human and mouse tissues. This antibody cross-reacts slightly with RAR alpha when expressed in COS cells, though the level of signal on Western blots is very low relative to that seen with RAR beta. It does not detect RAR alpha or gamma from cell lines or tissue extract.

MA1-811 has been successfully used in Western blot procedures. By Western blot, this antibody detects an ~52 kDa protein in rat tissue extract representing RAR beta. Also, by Western blot MA1-811 detects an unidentified ~120 kDa protein which can be competed away with the immunizing peptide. This protein is most notable in human SH-SY5Y and COS cells. Due to the extremely low levels of RAR expressed in native tissues, it is recommended that sensitive detection systems, such as enhanced chemiluminescence, be used.

The MA1-811 immunogen is a synthetic peptide corresponding to the C-terminal sequence of mouse RAR beta.

Reconstitute with PBS.

MA1-811 can be used with blocking peptide PEP-005.

靶标信息

Retinoic Acid (RA; active metabolite of vitamin A) plays a prominent role in regulating the transition of proliferating precursor cells (such as carcinoma cells and neuronal precursors) to postmitotic differentiated cells. The Retinoid X Receptors (RXRs) family (RXR alpha, beta, and gamma), preferentially bind 9-cis -RA and regulate gene transcription by forming heterodimers with a second family of RA receptors. RAs have been suggested to potentially play a therapeutic role in cervical cancer. RAs are known to play key roles in neuronal development and an increasing body of evidence indicates that retinoid signaling may regulate synaptic plasticity and associated learning and memory behaviors.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

生物信息学

蛋白别名: HBV-activated protein; hepatitis B virus activated protein; Nuclear receptor subfamily 1 group B member 2; nuclear receptor; RAR beta; open reading frame 1; putative; RAR beta; RAR beta 1'; RAR-b; RAR-beta; RAR-Beta2; RAR-Beta4; RAR-epsilon; RARB; RARbeta isoform 5; retinoic acid; retinoic acid receptor; Retinoic acid receptor beta; retinoic acid receptor, beta polypeptide; unnamed protein product

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基因别名: A830025K23; HAP; MCOPS12; NR1B2; RARB; RARbeta; RARbeta1; RRB2

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UniProt ID: (Human) P10826, (Mouse) P22605

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Entrez Gene ID: (Human) 5915, (Rat) 24706, (Mouse) 218772

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功能
RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding DNA binding transcription factor activity, sequence-specific DNA binding RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding protein binding zinc ion binding sequence-specific DNA binding macromolecular complex binding metal ion binding retinoid X receptor binding heterocyclic compound binding sequence-specific double-stranded DNA binding RNA polymerase II regulatory region sequence-specific DNA binding steroid hormone receptor activity retinoic acid receptor activity drug binding protein complex binding C4 zinc finger nuclear receptor
参与通路
negative regulation of transcription from RNA polymerase II promoter ureteric bud development glandular epithelial cell development outflow tract septum morphogenesis growth plate cartilage development regulation of transcription, DNA-templated apoptotic process signal transduction cell proliferation programmed cell death striatum development neurogenesis cell differentiation regulation of myelination negative regulation of chondrocyte differentiation embryonic hindlimb morphogenesis multicellular organism growth positive regulation of apoptotic process negative regulation of apoptotic process positive regulation of programmed cell death positive regulation of transcription from RNA polymerase II promoter embryonic eye morphogenesis retinoic acid receptor signaling pathway embryonic digestive tract development ventricular cardiac muscle cell differentiation bone development negative regulation of cartilage development neural precursor cell proliferation stem cell proliferation negative regulation of stem cell proliferation retinal pigment epithelium development transcription, DNA-templated positive regulation of cell proliferation negative regulation of cell proliferation steroid hormone mediated signaling pathway positive regulation of neuron differentiation retina development in camera-type eye regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter
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