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Proteintech
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Immunogen sequence: SSGRRDPKS VEQPIVLKEG FMIKRAQGRK RFGMKNFKKR WFRLTNHEFT YHKSKGDQPL YSIPIENILA VEKLEEESFK MKNMFQVIQP ERALYIQANN CVEAKDWIDI LTKVSQCNQK RLTVYHPSAY LSGHWLCCRA PSDSAPGCSP CTGGLPANIQ LDIDGDRETE RIYSLFNLYM SKLEKMQEAC GSKSVYDGPE QEEYSTFVID DPQETYKTLK QVIAGVGALE QEHAQYKRDK FKKTKYGSQE HPIGDKSFQN YIRQQSETST HSI (563-834 aa encoded by BC038456)
The protein encoded by this gene is member of the GAP1 family of GTPase-activating proteins. The gene product stimulates the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. This family member is an inositol 1, 3, 4, 5-tetrakisphosphate-binding protein, like the closely related RAS p21 protein activator 2. The two family members have distinct pleckstrin-homology domains, with this particular member having a domain consistent with its localization to the plasma membrane.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: GAP1(IP4BP); GAP1m; GapIII; GAPIII activator 3; GTPase activating protein III; GTPase-activating protein 1 family, inositol 1,3,4,5-tetrakisphosphate-binding protein; GTPase-activating protein 1m; GTPase-activating protein of RAS; Ins P4-binding protein; Ins(1,3,4,5)P4-binding protein; R-Ras gap; R-ras RTPase activating protein-3; Ras GTPase-activating protein 2; Ras GTPase-activating protein 3; Ras GTPase-activating protein III
基因别名: 5430433H21Rik; AA517451; AI326412; AU023900; C86362; E130011G04; GAP1IP4BP; GAP1M; GAPIII; RASA2; RASA3; RASGAP; scat
UniProt ID: (Human) Q15283, (Human) Q14644, (Mouse) P58069, (Mouse) Q60790
Entrez Gene ID: (Human) 5922, (Human) 22821, (Mouse) 114713, (Mouse) 19414