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Invitrogen
RASA4 Polyclonal Antibody
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产品信息
PA5-60197
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
形式
Liquid
浓度
0.7 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: MSSSFKKLYF SLTTEALSFA KTPSSKKSAL IKLANIRAAE KVEEKSFGGS HVMQVIYTDD AGRPQTAYLQ CKC
Highest antigen sequence identity to the following orthologs: Mouse - 85%, Rat - 86%.
靶标信息
This gene encodes a member of the GAP1 family of GTPase-activating proteins that suppresses the Ras/mitogen-activated protein kinase pathway in response to Ca(2+). Stimuli that increase intracellular Ca(2+) levels result in the translocation of this protein to the plasma membrane, where it activates Ras GTPase activity. Consequently, Ras is converted from the active GTP-bound state to the inactive GDP-bound state and no longer activates downstream pathways that regulate gene expression, cell growth, and differentiation. Multiple transcript variants encoding different isoforms have been found for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Ca2+-promoted Ras inactivator; Calcium-promoted Ras inactivator; Ras GTPase-activating protein 4; Ras p21 protein activator 4; RasGAP-activating-like protein 2
基因别名: CAPRI; GAPL; KIAA0538; RASA4
UniProt ID: (Human) O43374
Entrez Gene ID: (Human) 10156
