Abnova

RASGRP4 Polyclonal Antibody, MaxPab™

Name: RASGRP4 Polyclonal Antibody, MaxPab\u2122
Brand: Abnova
SKU: H00115727-D01P

查看其他5个RASGRP4抗体

说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

抗体检测数据 (2)

图: 1 / 2

RASGRP4 Antibody (H00115727-D01P) in WB

Western Blot analysis of RASGRP4 expression in transfected 293T cell line (H00115727-T01) by RASGRP4 MaxPab polyclonal antibody.

Lane 1: RASGRP4 transfected lysate(74.90 KDa).
Lane 2: Non-transfected lysate.

RASGRP4 Antibody in Proximity Ligation Assay (PLA) (PLA)

Product Image Gallery

Immunogen image

Immunogen Image RASGRP4 Polyclonal Antibody, MaxPab™

产品信息

H00115727-D01P

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1-5 µg/mL

Proximity Ligation Assay (PLA) (PLA)

1:1200

产品规格

种属反应

Human

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

RASGRP4 (NP_733749.1, 1 a.a. approximately 673 a.a) full-length human protein.

查看免疫原

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

See Label

纯化类型

Affinity chromatography

保存液

PBS, pH 7.4

内含物

no preservative

保存条件

-20°C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

产品详细信息

Sequence of this protein is as follows: MNRKDSKRKS HQECTGKIGG RGRPRQVRRH KTCPSPREIS KVMASMNLGL LSEGGCSEDE LLEKCIQSFD SAGSLCHEDH MLNMVLAMHS WVLPSADLAA RLLTSYQKAT GDTQELRRLQ ICHLVRYWLM RHPEVMHQDP QLEEVIGRFW ATVAREGNSA QRRLGDSSDL LSPGGPGPPL PMSSPGLGKK RKVSLLFDHL ETGELAQHLT YLEFRSFQAI TPQDLRSYVL QGSVRGCPAL EGSVGLSNSV SRWVQVMVLS RPGPLQRAQV LDKFIHVAQR LHQLQNFNTL MAVTGGLCHS AISRLKDSHA HLSPDSTKAL LELTELLASH NNYARYRRTW AGCAGFRLPV LGVHLKDLVS LHEAQPDRLP DGRLHLPKLN NLYLRLQELV ALQGQHPPCS ANEDLLHLLT LSLDLFYTED EIYELSYARE PRCPKSLPPS PFNAPLVVEW APGVTPKPDR VTLGRHVEQL VESVFKNYDP EGRGTISQED FERLSGNFPF ACHGLHPPPR QGRGSFSREE LTGYLLRASA ICSKLGLAFL HTFHEVTFRK PTFCDSCSGF LWGVTKQGYR CRECGLCCHK HCRDQVKVEC KKRPGAKGDA GPPGAPVPST PAPHASCGSE ENHSYTLSLE PETGCQLRHA WTQTESPHPS WETDTVPCPV MDPPSTASSK LDS

靶标信息

The RASGRP4 (RAS Guanyl Releasing Protein 4) gene encodes a guanine nucleotide exchange factor (GEF) that specifically activates RAS proteins by facilitating the exchange of GDP for GTP. Located on chromosome 19, RASGRP4 is expressed primarily in hematopoietic cells, including mast cells and certain myeloid cells. The protein contains a diacylglycerol (DAG)-binding C1 domain, a Ras exchange motif, and a CDC25 domain, which are essential for its activation and function. RASGRP4 plays a pivotal role in signal transduction pathways that regulate cell proliferation, differentiation, and survival. Dysregulation of RASGRP4 has been linked to various diseases, including inflammatory disorders and cancers, particularly those involving the hematopoietic system. Studies have shown that overexpression or mutations in RASGRP4 can lead to aberrant RAS signaling, contributing to oncogenesis and disease progression.

仅用于科研。不用于诊断过程。未经明确授权不得转售。