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Invitrogen
RASGRP4 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-21597
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Carrier-protein conjugated synthetic peptide encompassing a sequence within the N-terminus region of human RASGRP4. The exact sequence is proprietary.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7, with 40% glycerol
内含物
0.01% thimerosal
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Recommended positive controls: Jurkat.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
The RASGRP4 (RAS Guanyl Releasing Protein 4) gene encodes a guanine nucleotide exchange factor (GEF) that specifically activates RAS proteins by facilitating the exchange of GDP for GTP. Located on chromosome 19, RASGRP4 is expressed primarily in hematopoietic cells, including mast cells and certain myeloid cells. The protein contains a diacylglycerol (DAG)-binding C1 domain, a Ras exchange motif, and a CDC25 domain, which are essential for its activation and function. RASGRP4 plays a pivotal role in signal transduction pathways that regulate cell proliferation, differentiation, and survival. Dysregulation of RASGRP4 has been linked to various diseases, including inflammatory disorders and cancers, particularly those involving the hematopoietic system. Studies have shown that overexpression or mutations in RASGRP4 can lead to aberrant RAS signaling, contributing to oncogenesis and disease progression.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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